Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Syrup
Brand Name: Cofles DMR
Composition: Dextromethorphan 15 mg.+Phenylephrine 5 mg.+ Cholrpheniramine 2 mg
MRP: 100
Packing: 100ml
Table of Contents
Product Overview
Cofles DMR is a scientifically formulated dextromethorphan hydrobromide and chlorpheniramine maleate syrup designed to provide effective relief from dry cough, throat irritation, allergic cough, and night-time cough symptoms.
Dry cough is one of the most common reasons for outpatient visits, especially during seasonal changes, pollution exposure, viral infections, and allergic conditions. Unlike productive coughs, dry cough does not help clear mucus and often worsens at night, affecting sleep and recovery.
The combination of dextromethorphan hydrobromide (a centrally acting cough suppressant) and chlorpheniramine maleate (a first-generation antihistamine) works together to control cough reflexes while reducing allergy-related triggers such as sneezing, runny nose, and throat itching.
Cofles DMR is widely prescribed by physicians for patients who need symptomatic relief without excessive sedation, making it suitable for controlled use in both adults and adolescents under medical guidance.
Key Highlights
Contains dextromethorphan hydrobromide and chlorpheniramine maleate syrup for effective dry cough control
Suppresses persistent cough reflex at the brain level
Reduces allergy-related triggers such as sneezing, nasal irritation, and throat itching
Helpful in night-time cough that disrupts sleep
Suitable for cold-induced, allergic, and post-viral cough
Manufactured under GMP-certified standards for quality and consistency
How Dextromethorphan Hydrobromide and Chlorpheniramine Maleate Syrup Works
Dextromethorphan Hydrobromide – Cough Suppression
Dextromethorphan acts on the cough center in the medulla oblongata of the brain. It suppresses the urge to cough without affecting normal breathing or clearing mechanisms.
Clinical studies show that dextromethorphan effectively reduces cough frequency and intensity in non-productive coughs, especially those associated with viral infections and environmental irritants
(Referenced from MedlinePlus & NCBI).
Chlorpheniramine Maleate – Allergy Control
Chlorpheniramine maleate is an H1 antihistamine that blocks histamine-mediated allergic responses. Histamine is responsible for symptoms such as:
Sneezing
Runny nose
Throat itching
Watery eyes
By reducing these triggers, chlorpheniramine supports dextromethorphan in controlling cough caused by allergic irritation
Together, this makes dextromethorphan hydrobromide and chlorpheniramine maleate syrup especially effective in dry coughs with an allergic component.
Uses & Indications for Cofles DMR
Cofles DMR is commonly prescribed for:
Dry cough
Allergic cough
Night-time cough disturbing sleep
Cough due to common cold
Post-viral cough
Throat irritation due to pollution or smoke
Sneezing and runny nose associated with cough
According to the sources, combinations like dextromethorphan hydrobromide and chlorpheniramine maleate syrup are most effective when cough is non-productive and allergy-driven, rather than mucus-filled.
Dosage and Administration
Typical guidance (may vary by patient):
Adults: As prescribed, usually 2–3 times daily
Children: Dose depends on age and weight (medical supervision required)
Administration tips:
Use a measuring cup or spoon for accuracy
Can be taken with or without food
Avoid alcohol while using this syrup
Do not exceed recommended dosage
Always follow a doctor’s advice.
Who Should Use This Syrup
Patients with persistent dry cough
Individuals with allergy-triggered cough
People experiencing cough that worsens at night
Patients exposed to pollution or smoke
Who Should Avoid or Use with Caution
As per MedlinePlus and NIH guidance:
Patients on MAO inhibitors
Individuals with glaucoma or urinary retention
Elderly patients (risk of drowsiness)
People operating heavy machinery if sedation occurs
- Avoid in patients with known hypersensitivity to ingredients
Common Myths & Misconceptions
Myth: Dry cough always needs antibiotics
Fact: Most dry coughs are viral or allergic; antibiotics are unnecessary
Myth: Stronger cough syrups work faster
Fact: Correct formulation matters more than strength
Myth: Dextromethorphan causes addiction at normal doses
Fact: Safe and non-addictive when used as prescribed (NIH)
Myth: Antihistamines are only for runny nose
Fact: They also reduce cough triggered by allergies
Mistakes People Commonly Make
Using wet-cough syrups for dry cough
Combining multiple cold medicines unknowingly
Stopping treatment too early
Using adult doses for children
Ignoring night-time cough as “normal”
Safety, Side Effects & Precautions
Possible side effects (usually mild):
Drowsiness
Dry mouth
Mild dizziness
Why Cofles DMR
Cofles DMR follows evidence-based formulation principles and WHO-GMP manufacturing standards, ensuring reliable relief from dry and allergic cough without unnecessary additives.
FAQ
Q1. What is dextromethorphan hydrobromide and chlorpheniramine maleate syrup used for?
Dry cough, allergic cough, night-time cough, and cold-related throat irritation.
Q2. Does it cause sleepiness?
Yes, mild drowsiness may occur due to chlorpheniramine
Q3. Can it be taken at night?
Yes, it is commonly prescribed for night-time cough relief
Q4. Is it safe for children?
Yes, when used in age-appropriate doses under medical supervision
Q5. How fast does it work?
Usually within 30–60 minutes after intake