Paracetamol Caffeine Diphenhydramine and Phenylephrine
Brand Name: Coldrox Plus
Composition: Phenylephrine Hcl 5 mg + Paracetamol 325 mg + Diphenhydramine Hcl 25 mg + Caffeine 30 mg
MRP: 550
Packing: 10×10 Blister
Table of Contents
Key Highlights
Coldrox Plus contains a powerful multi-symptom cold & flu relief formula with paracetamol caffeine diphenhydramine and phenylephrine.
Relieves fever, headache, nasal congestion, runny nose, sneezing, body pain & allergies.
Diphenhydramine reduces allergic symptoms; phenylephrine clears nasal passages; paracetamol reduces fever & pain; caffeine improves alertness.
Ideal for seasonal flu, viral colds, sinus congestion & allergic colds.
Manufactured in a WHO-GMP certified facility by Biozia Lifesciences
Product Overview
Coldrox Plus is a scientifically balanced cold & flu relief tablet containing paracetamol caffeine diphenhydramine and phenylephrine, designed to address multiple symptoms in one dose.
While paracetamol reduces fever and body aches, phenylephrine acts as a nasal decongestant, diphenhydramine manages runny nose & sneezing, and caffeine enhances alertness by countering drowsiness. It is commonly recommended for viral colds, headaches, sinus pressure, fever, and allergic symptoms.
For distributors and PCD partners, cold-combination tablets are among the highest-demand seasonal and year-round OTC medicines.
Indications for Paracetamol Caffeine Diphenhydramine and Phenylephrine
The combination is indicated for:
Common cold & viral fever
Headache, sinus pressure, and facial pain
Runny nose, sneezing, watery eyes
Body aches and fatigue
Allergic cold symptoms
Flu-like symptoms
Night-time cold relief (because of diphenhydramine’s antihistamine effect)
Paracetamol reduces fever, while phenylephrine decongests nasal pathways. Diphenhydramine is an antihistamine, and caffeine enhances paracetamol absorption and alertness
Mechanism of Action
Paracetamol
Reduces fever and pain by acting on the hypothalamus.
Reference: NCBI
Phenylephrine HCl
A nasal decongestant that shrinks swollen blood vessels in the nose.
Reference: MedlinePlus
Diphenhydramine HCl
A sedating H1 antihistamine that reduces sneezing, runny nose & watery eyes.
Reference: NIH
Caffeine
Mild stimulant that improves alertness and enhances analgesic effect of paracetamol.
Reference: PubMed
Together, the paracetamol caffeine diphenhydramine and phenylephrine combination provides broad-spectrum relief from cold, flu, sinus & allergy symptoms.
Dosage and Administration for Coldrox Plus
Adults: 1 tablet every 6–8 hours, or as prescribed.
Do not exceed 4 tablets in 24 hours.
Take after food to reduce stomach irritation.
Avoid alcohol (increases drowsiness & liver load with paracetamol).
Not recommended for children under 12 without medical guidance.
Avoid other antihistamines or decongestants unless approved.
General Health & Recovery Tips
Drink warm fluids (kadha, soups, herbal tea) to ease congestion.
Steam inhalation helps open nasal passages.
Get adequate rest; avoid strenuous activity.
Gargle with warm salt water for throat pain.
Stay hydrated to ease fever & congestion.
Use a humidifier at night if nose and throat feel dry
Myths & Facts
Myth: “Cold combinations cure infections.”
Fact: They relieve symptoms but do not kill viruses.
Myth: “More tablets mean faster recovery.”
Fact: Overdose of paracetamol can damage the liver.
Myth: “Cold medicines work instantly.”
Fact: They take 20–40 minutes for noticeable relief.
Myth: “Antibiotics are needed for every cold.”
Fact: Viral colds don’t require antibiotics.
Myth: “All cold tablets cause drowsiness.”
Fact: Diphenhydramine causes mild sedation — caffeine helps balance it.
Did You Know?
Phenylephrine primarily works on α-adrenergic receptors to open nasal passages.
Diphenhydramine is one of the oldest and most effective antihistamines globally.
Caffeine boosts the pain-relief strength of paracetamol by up to 40% (proven in studies).
Viral colds usually peak by day 2–3 and improve in 5–7 days — symptom management is key
Why Choose Biozia Lifesciences?
At Biozia Lifesciences Pvt. Ltd., we believe that quality healthcare should be affordable and accessible. Our products are:
Manufactured in WHO-GMP certified units.
Backed by strong quality testing at every stage.
Packed securely to maintain potency and shelf life.
Trusted by healthcare professionals across India.
We are more than just a pharmaceutical company — we are partners in improving community health.
Why Partner With Us?
Monopoly-based franchise rights.
Wide product range across antibiotics, nutraceuticals, pain relief, syrups, and more.
Attractive packaging and marketing materials (visual aids, brochures, samples).
Timely delivery and stock availability.
Dedicated business support to help you grow your pharma business.
👉 Contact us today to explore franchise opportunities in your region.
This information is provided for educational purposes only and does not substitute medical advice. Always consult a qualified physician or pharmacist before starting any medication. The use of this product must comply with local regulations. Biozia Lifesciences is not liable for misuse
FAQ
Q1. What is the use of paracetamol caffeine diphenhydramine and phenylephrine tablets?
They relieve fever, headache, nasal congestion, runny nose, and allergy symptoms
Q2. Does Coldrox Plus make you sleepy?
Diphenhydramine may cause mild sedation, but caffeine balances alertness.
Q3. How long does it take to work?
Relief usually begins in 20–40 minutes
Q4. Can I take this with other cold medicines?
Avoid additional paracetamol or antihistamines. Consult your doctor
Q5. Can I drive after taking Coldrox Plus?
Use caution — diphenhydramine may cause mild drowsiness