Paracetamol, Phenylephrine, Caffeine & Diphenhydramine Cold Tablets

Reviewed by Anil Kumar Goel, B.Pharm — Chairman, Biozia Lifesciences, 40+ years in the pharmaceutical industry.

Multi-symptom cold tablets that combine paracetamol, phenylephrine, caffeine and diphenhydramine are a familiar choice for the fever, aches, blocked nose and runny nose of the common cold. This guide explains what each ingredient does, how the tablets are used, important precautions, and how Biozia supplies them as Coldrox Plus Tablet.

Key takeaways (TL;DR)

Each tablet contains Paracetamol 325 mg, Phenylephrine HCl 5 mg, Diphenhydramine HCl 25 mg and Caffeine 30 mg.
Relieves fever, headache, body ache, nasal congestion, runny nose and sneezing from colds and flu.
Diphenhydramine causes drowsiness; caffeine partly offsets it.
Not for children, and use with caution in high blood pressure, heart disease and thyroid disease.
Biozia supplies Coldrox Plus (10×10 blister) for PCD franchise and third-party manufacturing.

Composition and available strengths

Biozia manufactures this cold and flu combination as:

Brand	Composition	Packing
Coldrox Plus Tablet	Phenylephrine Hcl 5 mg + Paracetamol 325 mg + Diphenhydramine Hcl 25 mg + Caffeine 30 mg	10X10 Blister

What each ingredient does

Paracetamol — lowers fever and relieves headache and body ache.
Phenylephrine — a nasal decongestant that shrinks swollen nasal blood vessels.
Diphenhydramine — an antihistamine that reduces runny nose, sneezing and watery eyes.
Caffeine — boosts the pain-relieving effect of paracetamol and counters some drowsiness.

Uses

Common cold and flu symptoms
Fever with headache and body ache
Blocked or runny nose and sneezing
Sinus congestion with headache

Dosage

Take as directed on the label or by a doctor, usually after food, for a few days only. Do not take with other paracetamol-containing products or other cold and cough medicines. Seek medical advice if fever lasts more than three days or symptoms worsen.

Side effects and precautions

Drowsiness, dizziness, dry mouth, restlessness, palpitations and difficulty sleeping can occur.

Not for children unless prescribed.
Use with caution in high blood pressure, heart disease, diabetes, thyroid disease, glaucoma or enlarged prostate.
Do not use with MAO inhibitors.
Avoid alcohol and driving if drowsy, and limit other caffeine intake.
Use in pregnancy and breastfeeding only on medical advice.

For distributors: PCD franchise and third-party manufacturing

Cold and flu tablets are a strongly seasonal, high-volume category at chemist counters and general practitioners. Coldrox Plus belongs to the Coldrox family, which also includes Coldrox-DMR and Coldrox Super, giving franchise partners a complete cough-and-cold lineup.

PCD franchise — stock Coldrox Plus under monopoly rights in your district. See PCD pharma franchise with Biozia.
Third-party manufacturing — get this formulation made under your own brand name. See third-party manufacturing services.
Quality — WHO-GMP and ISO certified manufacturing in Yamunanagar, Haryana, with batch-wise documentation and pan-India dispatch.

Interested in cold and flu tablets for your territory or your own brand? Enquire with Biozia Lifesciences →

Frequently asked questions

What is paracetamol, phenylephrine, caffeine and diphenhydramine used for?

It relieves common cold and flu symptoms: fever, headache, body ache, blocked or runny nose and sneezing.

Does this cold tablet cause sleepiness?

Diphenhydramine can cause drowsiness. Caffeine partly offsets it, but patients should avoid driving if they feel sleepy.

Can people with high blood pressure take it?

Phenylephrine and caffeine can raise blood pressure and heart rate, so people with hypertension or heart disease should take it only on medical advice.

Is Coldrox Plus available for PCD franchise?

Yes. Coldrox Plus is available for PCD franchise and can be manufactured under your own brand through third-party manufacturing.

This guide is for pharmacists, doctors, distributors and trade partners. It is general product information, not medical advice — patients should take any medicine only as prescribed by a registered medical practitioner.