Esmorest-DSR Capsule
Esomeprazole 40 mg+Domperidone (SR) 30 mg
| Composition | Esomeprazole 40 mg+Domperidone (SR) 30 mg |
|---|---|
| Packing | 10x10 Alu/Alu |
| MRP | ₹ 1550 |
| Dosage Form | Capsules |
About Esmorest-DSR Capsule
Esmorest-DSR Capsule combines Esomeprazole 40 mg with Domperidone SR 30 mg — a powerful dual-action formulation that reduces stomach acid production while simultaneously improving stomach emptying and reducing reflux symptoms.
The sustained-release (SR) Domperidone works over an extended period to keep gastric motility optimised throughout the day, while Esomeprazole provides potent, lasting acid suppression — together addressing both the cause and the symptoms of acid reflux more comprehensively than a PPI alone.
Uses of Esmorest-DSR Capsule
This medicine is commonly used for:
- Gastroesophageal reflux disease (GERD) with motility issues
- Heartburn, acid regurgitation, and bloating
- Gastroparesis (delayed stomach emptying)
- Nausea associated with gastric reflux
- Non-ulcer dyspepsia with reflux symptoms
Indications
Esmorest-DSR is indicated for the management of gastroesophageal reflux disease with associated symptoms of delayed gastric emptying, dyspepsia, and nausea. Esomeprazole provides potent acid suppression; Domperidone SR acts as a gastroprokinetic and antiemetic to improve oesophageal and gastric clearance, addressing both the acid and motility components of symptomatic GERD.
How Esmorest-DSR Capsule Works
Esomeprazole switches off the stomach's acid-producing pumps, dramatically reducing the amount of acid that can reflux into the food pipe. Domperidone helps the stomach empty its contents into the intestine more quickly and tightens the valve between the stomach and the food pipe — so there is less acid to reflux and less opportunity for it to escape upward.
Mechanism of Action
Esomeprazole, the S-enantiomer of Omeprazole, irreversibly inhibits the H+/K+-ATPase proton pump in gastric parietal cells after acid-mediated activation, providing sustained suppression of basal and stimulated acid output. Domperidone is a peripheral dopamine D2-receptor antagonist that enhances lower oesophageal sphincter (LES) tone, accelerates gastric emptying, and improves antroduodenal co-ordination. The sustained-release formulation of Domperidone prolongs its gastroprokinetic effect, extending motility improvement throughout the dosing interval.
Key Benefits
- Dual action on both acid production and gastric motility for comprehensive GERD management
- SR formulation of Domperidone ensures extended prokinetic effect throughout the day
- Reduces regurgitation, bloating, nausea, and heartburn together
- Esomeprazole's S-enantiomer chemistry provides more consistent acid suppression than racemic PPIs in many patients
Did You Know?
Esomeprazole is the S-enantiomer (one mirror-image form) of the older PPI Omeprazole. Because the body metabolises it differently, Esomeprazole achieves higher blood levels and more consistent acid suppression in a broader range of patients — which is why it was developed as an improvement over its predecessor.
When & How to Take
Esmorest-DSR Capsule should be taken 30 to 60 minutes before a meal, preferably in the morning, as directed by your doctor. Do not crush or chew the capsule — swallow it whole to preserve the sustained-release mechanism of Domperidone.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include headache, dry mouth, diarrhoea, or mild abdominal discomfort. Domperidone may cause mild prolactin elevation in some patients with long-term use. These are usually mild and manageable. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Swallow the capsule whole — do not crush or open, as this will destroy the SR mechanism
- Take before meals for maximum acid suppression at mealtimes
- Inform your doctor if you have any heart rhythm problems, as Domperidone may interact with conditions or medicines affecting the QT interval
- Avoid concurrent use with strong CYP3A4 inhibitors (e.g. certain antifungals) — inform your doctor of all medications
- Long-term PPI use should be periodically reviewed with your doctor
Myths vs Facts
Antacids and PPIs do the same thing.
Antacids neutralise acid that is already in the stomach for quick short-term relief. PPIs like Esomeprazole block the production of acid at its source, providing longer-lasting suppression and healing of acid-damaged tissue.
GERD is just a lifestyle issue and does not need medication.
While lifestyle changes are important, GERD involves physiological factors including lower oesophageal sphincter dysfunction and acid hypersecretion that often require medical management to prevent complications like oesophagitis.
