Ziarab-DSR Capsule
Rabeprazole 20 mg + Domperidone 30 mg(Sustained Release)
| Composition | Rabeprazole 20 mg + Domperidone 30 mg(Sustained Release) |
|---|---|
| Packing | 10x10 Alu/Alu |
| MRP | ₹ 1250 |
| Dosage Form | Capsules |
About Ziarab-DSR Capsule
Ziarab-DSR Capsule contains Rabeprazole 20 mg and Domperidone 30 mg (Sustained Release), a dual-action combination targeting both excess stomach acid and sluggish gastric motility. Rabeprazole quickly suppresses acid production, while the sustained-release Domperidone is released gradually to provide smooth, prolonged improvement in gastric movement throughout the day.
Ziarab-DSR is indicated for patients with acid reflux, GERD, or functional dyspepsia who also experience nausea, bloating, or regurgitation due to delayed gastric emptying. This formulation is equivalent in composition to Rabzia-DSR and delivers the same clinical benefits through Biozia's Ziarab brand.
Uses of Ziarab-DSR Capsule
This medicine is commonly used for:
- Acid reflux and heartburn with associated nausea
- Gastroesophageal reflux disease (GERD) with motility issues
- Bloating, regurgitation, and early satiety
- Functional dyspepsia with combined acid and motility symptoms
- Nausea due to delayed gastric emptying
Indications
Rabeprazole 20 mg + Domperidone 30 mg SR is indicated for the management of gastroesophageal reflux disease with concurrent gastric dysmotility, functional dyspepsia with acid hypersecretion and delayed gastric emptying, and nausea and regurgitation associated with gastroparesis. The sustained-release formulation of Domperidone ensures maintained therapeutic plasma concentrations and prolonged prokinetic support from a single daily dose.
How Ziarab-DSR Capsule Works
Ziarab-DSR works by combining fast acid control with extended motility support. Rabeprazole rapidly switches off the stomach's acid pumps, reducing acid and allowing the gut lining to heal. The sustained-release Domperidone is released steadily throughout the day, helping food move through the stomach efficiently and easing nausea, bloating, and the uncomfortable feeling of a full stomach long after eating.
Mechanism of Action
Rabeprazole irreversibly inhibits the gastric H+/K+ ATPase (proton pump) in parietal cells following acid activation, providing rapid and consistent acid suppression with relatively low CYP2C19-dependent interindividual variability. Domperidone (SR) antagonizes peripheral dopamine D2 receptors in the gastric antrum and duodenum, enhancing peristalsis, increasing lower esophageal sphincter pressure, and accelerating gastric emptying; the sustained-release matrix maintains therapeutic plasma concentrations over 24 hours, optimizing the duration of prokinetic effect.
Key Benefits
- Rapid acid suppression with Rabeprazole for quick heartburn relief
- Sustained-release Domperidone provides consistent all-day motility support
- Addresses both acid excess and motility impairment in one capsule
- Once-daily dosing with extended-release convenience
Did You Know?
Rabeprazole reaches its maximum acid-suppressing effect faster on Day 1 of therapy compared to some other PPIs, making it a useful option when rapid symptom relief is a priority.
When & How to Take
Ziarab-DSR is generally taken once daily before a meal, as directed by your doctor. The sustained-release capsule must be swallowed whole — do not crush, break, or chew it. Follow your doctor's prescribed dose and duration.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Ziarab-DSR is generally well tolerated. Possible mild side effects include headache, diarrhea, dry mouth, or mild stomach discomfort. Domperidone may rarely affect heart rhythm. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Swallow the capsule whole — crushing destroys the sustained-release mechanism
- Inform your doctor of any heart conditions before starting this medicine
- Provide your doctor a full list of all medicines you take, as several drug interactions are possible
- Not recommended during pregnancy or breastfeeding without medical guidance
- Long-term use should be reviewed and supervised by your doctor
Myths vs Facts
All PPI + Domperidone combinations are identical — brand doesn't matter.
While the active ingredients may be similar, differences in formulation — such as the sustained-release technology in the Domperidone component — can meaningfully affect how steadily and how long the medicine works. Always use the specific product your doctor has prescribed.
If I feel better after a few days, my acid problem is cured and I can stop.
Symptom relief typically occurs before the underlying inflammation or mucosal damage has healed. Completing the full prescribed course — even after feeling better — ensures proper healing and reduces the risk of relapse.
