Ziaxone-250 Injection
Ceftriaxone 250 mg
| Composition | Ceftriaxone 250 mg |
|---|---|
| Packing | Vial+Wfi |
| MRP | ₹ 30 |
| Dosage Form | Injections |
About Ziaxone-250 Injection
Ziaxone-250 Injection contains Ceftriaxone 250 mg, a lower-strength formulation of the third-generation cephalosporin antibiotic Ceftriaxone. This dose is particularly suitable for paediatric patients and for treating specific infections that require a lighter but effective antibiotic course.
From Biozia Lifesciences, Ziaxone-250 provides the same broad-spectrum antibacterial action as higher-strength Ceftriaxone formulations, with the dosage calibrated for children and specific adult indications such as uncomplicated gonorrhoea.
Uses of Ziaxone-250 Injection
This medicine is commonly used for:
- Treating bacterial infections in infants and young children
- Managing uncomplicated gonorrhoea in adults (single-dose treatment)
- Treating mild to moderate respiratory and urinary tract infections
- Managing ear infections (otitis media) in children
- Surgical prophylaxis in appropriate clinical settings
Indications
Indicated for susceptible bacterial infections in paediatric patients including neonatal sepsis (excluding jaundiced or hyperbilirubinaemic neonates), community-acquired pneumonia, acute otitis media, urinary tract infections, and skin and soft-tissue infections. In adults, indicated for uncomplicated gonococcal infections (single-dose intramuscular administration) and as prophylactic coverage in minor surgical procedures. Dose is weight-adjusted for paediatric use under specialist guidance.
How Ziaxone-250 Injection Works
Ziaxone-250 works the same way as other Ceftriaxone formulations — it attacks and breaks down the cell wall of bacteria, killing them and stopping the infection from spreading. The 250 mg strength is carefully calibrated for smaller patients or for infections that require a lighter effective dose, ensuring the right amount of antibiotic reaches the site of infection.
Mechanism of Action
Ceftriaxone inhibits bacterial cell wall biosynthesis through irreversible binding to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking and inducing bacterial autolysis. The drug achieves therapeutic tissue concentrations at the 250 mg dose for susceptible organisms in specific anatomical sites. Its pharmacokinetic profile — characterised by a half-life of approximately 8 hours — supports effective once-daily dosing even at lower doses, with excellent penetration into middle ear fluid, urinary tract, and skin tissues.
Key Benefits
- Appropriate lower dose for paediatric patients and specific adult indications
- Same broad-spectrum cephalosporin coverage as higher-strength formulations
- Effective as a single-dose treatment for uncomplicated gonorrhoea
- Once-daily dosing supported by long half-life of Ceftriaxone
Did You Know?
A single 250 mg intramuscular injection of Ceftriaxone is the WHO-recommended treatment for uncomplicated gonorrhoea — making it one of the few infections treated effectively with just one injection.
When & How to Take
Ziaxone-250 Injection is given as an intramuscular or intravenous injection by a healthcare professional, as prescribed by your doctor. For children, the dose is calculated based on body weight. Always complete the full course as directed by your doctor.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Side effects are similar to other Ceftriaxone formulations and may include pain at the injection site, diarrhoea, nausea, and skin rash. Allergic reactions may rarely occur. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Not recommended in jaundiced neonates or those receiving intravenous calcium-containing fluids
- Inform your doctor of any history of allergy to cephalosporins or penicillins
- Use under specialist guidance in premature infants and neonates
- Complete the prescribed course even if symptoms resolve early
- Inform your doctor of all concurrent medications, particularly aminoglycosides
Myths vs Facts
Lower-dose antibiotics are less effective and won't clear the infection.
The dose is matched to the type of infection and patient. For specific conditions like uncomplicated gonorrhoea or ear infections, 250 mg of Ceftriaxone is clinically proven to be fully effective.
Ceftriaxone injections are painful and should be avoided.
While intramuscular injections can cause mild discomfort, the injection is often prepared with a local anaesthetic (lidocaine) to reduce pain. The benefit of the antibiotic outweighs brief discomfort.
