Ziaxone-500 Injection
Ceftriaxone 500 mg
| Composition | Ceftriaxone 500 mg |
|---|---|
| Packing | Vial+Wfi |
| MRP | ₹ 50 |
| Dosage Form | Injections |
About Ziaxone-500 Injection
Ziaxone-500 Injection contains Ceftriaxone 500 mg, a mid-strength formulation of the third-generation cephalosporin antibiotic that bridges the gap between the lower paediatric dose (250 mg) and the full adult dose (1000 mg). It is used for moderate bacterial infections in adults and weight-appropriate dosing in older children.
Biozia Lifesciences' Ziaxone-500 delivers effective broad-spectrum antibacterial coverage for a range of infections while offering flexibility in dose tailoring — particularly useful when the infection severity or patient parameters call for a half-gram dose.
Uses of Ziaxone-500 Injection
This medicine is commonly used for:
- Treating moderate respiratory tract infections including pneumonia
- Managing urinary tract infections requiring injectable antibiotic therapy
- Treating skin and soft-tissue infections
- Managing pelvic inflammatory disease
- Weight-appropriate dosing in paediatric patients for moderate infections
Indications
Indicated for the treatment of moderate to severe susceptible bacterial infections in adults and weight-appropriate paediatric patients including community-acquired pneumonia, complicated urinary tract infections, skin and soft-tissue infections, pelvic inflammatory disease, typhoid fever, and as surgical prophylaxis. Provides a dose step between 250 mg (paediatric/single-dose adult use) and 1 g (standard adult severe infection dosing), supporting individualised dosing decisions.
How Ziaxone-500 Injection Works
Ziaxone-500 works by weakening and breaking down the cell wall that bacteria need to survive. Once the wall is disrupted, the bacteria die and the body's immune system can clear the remaining infection. The 500 mg dose is effective for moderate infections, and since Ceftriaxone has a long duration of action in the body, it is typically given once daily.
Mechanism of Action
Ceftriaxone 500 mg achieves therapeutic plasma and tissue concentrations adequate for susceptible organisms causing moderate infections. The drug binds to and inactivates penicillin-binding proteins (PBPs), particularly PBP-1a and PBP-3, disrupting peptidoglycan cross-linkage in bacterial cell walls. Its extended half-life (~8 hours) and 95% protein binding allow prolonged free-drug exposure above the minimum inhibitory concentration (MIC) for most susceptible pathogens, supporting once-daily parenteral therapy.
Key Benefits
- Flexible mid-strength dosing for moderate infections in adults and older children
- Broad-spectrum third-generation cephalosporin coverage
- Once-daily dosing due to long half-life
- Effective across multiple infection sites: lungs, urinary tract, skin, and pelvic organs
Did You Know?
Ceftriaxone is unique among cephalosporins in that it is eliminated from the body by both the liver (via bile) and the kidneys — making dose adjustment less critical in mild to moderate single-organ impairment compared to most other antibiotics.
When & How to Take
Ziaxone-500 Injection is administered by a healthcare professional intravenously or intramuscularly, as directed by your doctor. The number of doses per day and total duration of treatment are determined by the type and severity of your infection.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include pain or redness at the injection site, diarrhoea, nausea, and skin rash. Allergic reactions may occur rarely. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Inform your doctor of any allergy to cephalosporins, penicillins, or other beta-lactam antibiotics
- Do not mix with calcium-containing infusion solutions
- Use with caution in patients with severe liver or kidney impairment
- Not recommended in jaundiced or hyperbilirubinaemic neonates
- Always complete the full prescribed antibiotic course
Myths vs Facts
500 mg is half as effective as 1000 mg of Ceftriaxone.
Antibiotic effectiveness depends on whether drug levels exceed the MIC of the bacteria, not simply on the dose. For moderate infections with susceptible organisms, 500 mg provides adequate and effective coverage.
Injectable antibiotics always need to be given multiple times a day.
Ceftriaxone's long half-life means once-daily dosing is sufficient for most indications — even at 500 mg — making treatment convenient and adherence easier.
