Mefzia-P Suspension
Mefenamic Acid 100 mg + Paracetamol 250 mg
| Composition | Mefenamic Acid 100 mg + Paracetamol 250 mg |
|---|---|
| Packing | 60ML |
| MRP | ₹ 75 |
| Dosage Form | Syrups & Suspensions |
About Mefzia-P Suspension
Mefzia-P Suspension is a higher-strength analgesic and antipyretic suspension containing Mefenamic Acid 100 mg and Paracetamol 250 mg per 5 ml. Suitable for older children and adults who require a more potent oral analgesic in liquid form, it combines the anti-inflammatory and pain-relieving properties of Mefenamic Acid with the well-tolerated antipyretic and analgesic action of Paracetamol.
Mefzia-P Suspension is commonly prescribed for managing moderate pain and fever where a combination product offers better efficacy and tolerability than either medicine given alone at higher individual doses.
Uses of Mefzia-P Suspension
This medicine is commonly used for:
- Relieving moderate pain including headache, dental pain, and muscular aches
- Reducing fever in older children and adults
- Managing pain from ear infections, throat infections, and sinusitis
- Relieving inflammatory pain in conditions such as sprains or mild arthritis flares
- Post-procedural or post-extraction pain relief
Indications
Mefzia-P Suspension is indicated for the symptomatic management of mild to moderate pain and pyrexia in older paediatric and adult patients. It is used in conditions including musculoskeletal pain, dental pain, dysmenorrhoea, otitis media, pharyngitis, tonsillitis, febrile illness, and post-operative or post-procedural pain. Mefenamic Acid provides peripherally and centrally acting NSAID analgesia and anti-inflammatory activity; Paracetamol provides centrally mediated analgesia and antipyresis with gastric tolerability, allowing a combination of complementary mechanisms at lower individual doses.
How Mefzia-P Suspension Works
Mefzia-P Suspension works through two complementary pathways: Mefenamic Acid blocks the enzymes responsible for producing pain and inflammation chemicals at the source of pain, while Paracetamol acts in the brain and spinal cord to raise the pain threshold and lower fever. This dual approach means faster, more complete relief from pain and fever without needing high doses of either ingredient alone.
Mechanism of Action
Mefenamic Acid is a non-selective COX-1 and COX-2 inhibitor of the anthranilic acid (fenamate) subclass of NSAIDs. It inhibits prostaglandin synthetase peripherally, reducing inflammatory prostaglandin E2 and F2α production at the site of tissue injury, and also directly antagonises prostaglandin receptors. This dual prostaglandin pathway blockade provides analgesic, anti-inflammatory, and mild antipyretic activity. Paracetamol suppresses hypothalamic prostaglandin synthesis for antipyresis and modulates central pain pathways including COX-3 inhibition and descending serotonergic system potentiation for analgesia. The mechanistic complementarity of peripheral NSAID action and central Paracetamol action provides synergistic efficacy with an improved tolerability profile.
Key Benefits
- Stronger combination suitable for moderate pain in adults and older children
- Dual-mechanism analgesic provides more complete pain and fever control
- Paracetamol reduces the NSAID dose needed, improving stomach tolerability
- Liquid suspension form for patients who cannot swallow tablets
Did You Know?
Mefenamic Acid is one of the few NSAIDs that can both block the production of prostaglandins AND block their action at tissue receptors. This two-pronged approach makes it particularly effective for conditions like dysmenorrhoea (painful periods), where prostaglandins play a central role in causing uterine cramping.
When & How to Take
Mefzia-P Suspension should be taken as directed by your doctor, preferably with or after food to minimise stomach irritation from Mefenamic Acid. Shake well before use. Do not take more than the prescribed dose or for longer than recommended.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Mefenamic Acid may cause nausea, stomach discomfort, or loose stools, particularly on an empty stomach. Paracetamol is generally well tolerated. Prolonged use of NSAIDs without medical supervision is not recommended. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Always take with or after food to reduce gastric irritation
- Avoid taking alongside other NSAID medicines without medical advice
- Do not combine with additional paracetamol-containing products
- Inform your doctor if you have kidney, liver, stomach ulcer, or heart conditions
- Not recommended for prolonged self-medication — always use under doctor's guidance
Myths vs Facts
Pain suspensions are less effective than tablets.
Liquid suspensions can actually be absorbed faster than solid tablets because they do not need to disintegrate first. Mefzia-P Suspension can deliver rapid, reliable pain relief — especially useful when swallowing tablets is difficult.
If pain is still present after one dose, taking a second dose immediately will help.
Taking doses too close together increases the risk of side effects without improving pain relief. NSAIDs need time to build up their effect. Always follow the prescribed dosing interval and consult your doctor if pain is not controlled.
