Ziacet-M Syrup
Levocetirizine Hcl 2.5 mg + Montelukast 4 mg
| Composition | Levocetirizine Hcl 2.5 mg + Montelukast 4 mg |
|---|---|
| Packing | 60ML |
| MRP | ₹ 100 |
| Dosage Form | Syrups & Suspensions |
About Ziacet-M Syrup
Ziacet-M Syrup combines Levocetirizine HCl 2.5 mg and Montelukast 4 mg in a syrup formulation, providing dual-action relief from allergic symptoms by targeting two different pathways involved in allergic reactions.
This combination by Biozia is commonly prescribed for children with allergic rhinitis, asthma-related symptoms, and urticaria, offering the antihistamine effect of Levocetirizine alongside the anti-leukotriene action of Montelukast for more comprehensive allergy and airway symptom control.
Uses of Ziacet-M Syrup
This medicine is commonly used for:
- Allergic rhinitis (seasonal and perennial) — sneezing, runny nose, nasal congestion
- Allergic skin reactions such as hives (urticaria) and itching
- Asthma symptom management and prevention of exercise-induced bronchoconstriction
- Relief from watery, itchy eyes due to allergy
- Prevention and management of recurrent allergic attacks in children
Indications
Levocetirizine + Montelukast combination is indicated for the symptomatic management of allergic rhinitis (seasonal and perennial), chronic idiopathic urticaria, and as adjunctive therapy in mild to moderate persistent asthma, particularly in patients with co-existing allergic rhinitis. Levocetirizine provides H1-receptor antagonism to reduce histamine-mediated allergic symptoms; Montelukast blocks cysteinyl leukotriene (CysLT1) receptors to attenuate leukotriene-driven bronchoconstriction, mucus secretion, and airway inflammation.
How Ziacet-M Syrup Works
During an allergic reaction, the body releases chemicals like histamine and leukotrienes that cause sneezing, runny nose, itching, and airway tightening. Levocetirizine blocks histamine receptors to quickly relieve symptoms like itching, sneezing, and watery eyes. Montelukast blocks leukotriene receptors to reduce airway inflammation and mucus, helping to keep airways open and prevent allergy-triggered breathing difficulties.
Mechanism of Action
Levocetirizine, the active R-enantiomer of cetirizine, is a second-generation H1 antihistamine with high affinity and selectivity for peripheral H1 receptors, with minimal anticholinergic and sedative activity. It competitively antagonises histamine-mediated vasodilation, pruritus, and bronchoconstriction. Montelukast is a selective, competitive antagonist of cysteinyl leukotriene type 1 (CysLT1) receptors on airway smooth muscle and mucosa, blocking the pro-inflammatory and bronchoconstricting effects of leukotrienes C4, D4, and E4 produced by the 5-lipoxygenase pathway. The dual blockade of histamine and leukotriene pathways provides broader control of allergic inflammation than either agent alone.
Key Benefits
- Dual-pathway allergy control — addresses both histamine and leukotriene components
- Low sedating profile of Levocetirizine allows use during daytime without drowsiness
- Particularly helpful in children with combined allergic rhinitis and asthma
- Syrup form allows easy, accurate dosing for paediatric patients
Did You Know?
Montelukast was one of the first medicines specifically developed to block leukotriene receptors. Leukotrienes are up to 1,000 times more potent than histamine in causing airway constriction, which is why blocking them separately from histamine provides significantly better asthma control.
When & How to Take
Ziacet-M Syrup is typically taken once daily in the evening, as prescribed by your doctor. Shake well before use. It may be taken with or without food. Follow your doctor's guidance on the duration of treatment.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include mild drowsiness, dry mouth, headache, or stomach discomfort. Levocetirizine is less sedating than older antihistamines, but some individuals may still feel slightly sleepy. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Avoid activities requiring full alertness (such as driving) until you know how this syrup affects you, as some drowsiness may occur
- Inform your doctor if your child has kidney problems, as the dose may need adjustment
- Do not use Montelukast-containing products if there is a history of neuropsychiatric reactions to this medicine
- This is not a reliever (rescue) medicine for acute asthma attacks — continue any prescribed rescue inhalers
- Store in a cool, dry place and keep out of reach of children
Myths vs Facts
Antihistamines alone are enough to control asthma-related allergy symptoms.
Histamine is only one of several mediators of allergic airway inflammation. Leukotrienes play a major role in asthma, and blocking only histamine may leave significant airway inflammation untreated. That is why the combination of Levocetirizine and Montelukast provides better control than antihistamine alone.
Children will feel very sleepy on antihistamine syrups and cannot study or play.
Levocetirizine is a second-generation antihistamine with a much lower sedating profile than older antihistamines like chlorpheniramine. Most children tolerate it well without significant drowsiness, especially when taken in the evening.
