Esmorest-LSR Capsule
Esomeprazole 40mg . Levosulpride 75mg
| Composition | Esomeprazole 40mg . Levosulpride 75mg |
|---|---|
| Packing | 10x10 Alu/Alu |
| MRP | ₹ 2500 |
| Dosage Form | Capsules |
About Esmorest-LSR Capsule
Esmorest-LSR Capsule is a combination of Esomeprazole 40 mg and Levosulpride 75 mg — an innovative pairing of a potent proton pump inhibitor with a prokinetic and antiemetic agent that acts on dopamine receptors to improve gut motility and reduce nausea.
Levosulpride, unlike Domperidone, also has a central antiemetic component that makes this combination particularly effective when GERD symptoms are accompanied by persistent nausea, bloating, or functional dyspepsia.
Uses of Esmorest-LSR Capsule
This medicine is commonly used for:
- Gastroesophageal reflux disease (GERD) with prominent nausea
- Functional dyspepsia and bloating
- Heartburn and acid regurgitation
- Gastroparesis and delayed stomach emptying
- Nausea and vomiting associated with gastric disorders
Indications
Esmorest-LSR is indicated for the management of GERD with associated dysmotility symptoms including nausea, bloating, early satiety, and functional dyspepsia. Esomeprazole provides sustained acid suppression; Levosulpride, a selective D2-receptor antagonist with central and peripheral prokinetic and antiemetic properties, improves gastrointestinal motility and controls associated nausea more comprehensively than peripheral-only prokinetics.
How Esmorest-LSR Capsule Works
Esomeprazole potently reduces stomach acid production for lasting relief from heartburn and acid reflux. Levosulpride works both in the gut — improving the movement of food through the stomach and intestine — and in the brain's nausea centre, providing effective control of nausea and vomiting that often accompanies chronic reflux and dyspepsia.
Mechanism of Action
Esomeprazole irreversibly blocks the H+/K+-ATPase proton pump in gastric parietal cells following protonation-mediated activation, suppressing gastric acid secretion throughout the day. Levosulpride is a selective benzamide D2-dopamine receptor antagonist with activity at both central (chemoreceptor trigger zone, CTZ) and peripheral (enteric nervous system) receptors. Centrally, it suppresses the dopamine-mediated emetic response; peripherally, it enhances cholinergic transmission in the myenteric plexus, increasing lower oesophageal sphincter pressure, accelerating gastric emptying, and coordinating antroduodenal motility.
Key Benefits
- Combines potent acid suppression with central and peripheral prokinetic action
- More effective control of nausea and vomiting than peripheral-only prokinetics
- Improves gastric emptying, reducing bloating and fullness
- Addresses the full symptom complex of GERD including acid, motility, and nausea
Did You Know?
Levosulpride is the levo-isomer of Sulpride — the specific optical form responsible for most of the drug's beneficial prokinetic and antiemetic effects, while being better tolerated than the racemic mixture. This chiral selectivity is a good example of how pharmaceutical refinement can improve a medicine's efficacy-to-side-effect ratio.
When & How to Take
Esmorest-LSR Capsule is best taken 30 to 60 minutes before a meal, as directed by your doctor. Swallow the capsule whole without opening or crushing it.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Possible side effects include drowsiness, dizziness, dry mouth, and headache. Levosulpride can elevate prolactin levels with prolonged use and may rarely cause extrapyramidal symptoms in susceptible individuals — inform your doctor promptly if you notice any unusual movements. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Inform your doctor if you have a history of any movement disorder, as Levosulpride has dopamine-blocking activity
- Use with caution in patients with pituitary tumours or a history of hormone-sensitive conditions
- Do not use in patients with suspected gastrointestinal obstruction or perforation
- Avoid concurrent use of other dopamine-blocking medications without medical advice
- Long-term use should be periodically reviewed by your doctor
Myths vs Facts
Esomeprazole alone is always enough to treat all GERD symptoms.
Acid suppression alone does not address the motility and nausea aspects of GERD. For patients with significant bloating, slow gastric emptying, or nausea, adding a prokinetic like Levosulpride provides more comprehensive symptom control.
Prokinetics only work in the stomach and have no central effects.
Levosulpride acts both in the gut and at the brain's chemoreceptor trigger zone — giving it a dual advantage of improving gut motility and directly suppressing the nausea signal in the brain.
