Rabzia-DSR Capsule
Rabeprazole 20 mg + Domperidone 30 mg(Sustained Release)
| Composition | Rabeprazole 20 mg + Domperidone 30 mg(Sustained Release) |
|---|---|
| Packing | 20x10 Alu/Alu |
| MRP | ₹ 2500 |
| Dosage Form | Capsules |
About Rabzia-DSR Capsule
Rabzia-DSR Capsule contains Rabeprazole 20 mg and Domperidone 30 mg (Sustained Release), providing dual-action relief for acid reflux and associated gastric motility problems. Rabeprazole rapidly suppresses excess stomach acid, while the sustained-release Domperidone component is released gradually to provide prolonged improvement in gastric movement throughout the day.
This combination is particularly well suited for patients who experience heartburn along with symptoms of delayed gastric emptying such as nausea, bloating, and regurgitation. The sustained-release formulation of Domperidone ensures a smoother, longer-lasting prokinetic effect with a single daily dose.
Uses of Rabzia-DSR Capsule
This medicine is commonly used for:
- Heartburn and acid reflux with associated nausea
- Gastroesophageal reflux disease (GERD) with motility issues
- Bloating, early satiety, and regurgitation
- Functional dyspepsia with acid and motility complaints
- Nausea due to delayed gastric emptying
Indications
Rabeprazole 20 mg + Domperidone 30 mg SR is indicated for the management of gastroesophageal reflux disease with concurrent gastric motility impairment, functional dyspepsia associated with hypersecretion and delayed gastric emptying, and symptomatic relief of nausea and regurgitation in gastroparesis. The sustained-release Domperidone formulation maintains therapeutic plasma concentrations for extended gastric motility support.
How Rabzia-DSR Capsule Works
Rabzia-DSR works on two fronts: Rabeprazole quickly switches off the stomach's acid-producing pumps, reducing acid and allowing the esophagus and stomach lining to heal. The sustained-release Domperidone helps food travel through the stomach and intestines at a healthy pace, easing nausea, bloating, and the uncomfortable feeling of a full stomach long after eating.
Mechanism of Action
Rabeprazole is a second-generation proton pump inhibitor that activates at a lower pH than earlier PPIs, allowing faster and more complete inhibition of the H+/K+ ATPase enzyme in gastric parietal cells with less interindividual variability due to CYP2C19 polymorphism. Domperidone (SR) is a peripheral dopamine D2 receptor antagonist that enhances antroduodenal peristalsis, increases lower esophageal sphincter pressure, and accelerates gastric emptying; the sustained-release formulation extends therapeutic plasma levels over 24 hours, reducing peak-related side effects.
Key Benefits
- Fast acid suppression with Rabeprazole for quick heartburn relief
- Sustained-release Domperidone provides all-day motility support
- Addresses both acid and motility components of reflux disease
- Once-daily convenience with extended-release technology
Did You Know?
Rabeprazole is unique among proton pump inhibitors because its activation is less dependent on the CYP2C19 liver enzyme, meaning its acid-suppressing effect is more consistent across patients regardless of their genetic metabolism type.
When & How to Take
Rabzia-DSR is generally taken once daily before a meal, as prescribed by your doctor. The sustained-release formulation is designed to work throughout the day, so follow your doctor's dosage instructions carefully and do not crush or chew the capsule.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Most people tolerate Rabzia-DSR well. Possible mild side effects include headache, diarrhea, dry mouth, or stomach discomfort. Domperidone may rarely affect heart rhythm. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Do not crush or chew the sustained-release capsule; swallow whole
- Inform your doctor of any heart conditions before taking this medicine
- Tell your doctor about all other medicines, particularly antifungals, macrolide antibiotics, or HIV medications
- Avoid in patients with liver impairment without medical guidance
- Not recommended during pregnancy or breastfeeding without a doctor's advice
Myths vs Facts
Sustained-release medicines are just marketing — they work the same as regular tablets.
Sustained-release technology genuinely controls the rate at which a drug is released into the bloodstream, resulting in steadier drug levels, fewer peaks that can cause side effects, and a longer duration of action — all real clinical benefits.
Domperidone can make you sleepy because it acts on the brain.
Domperidone is specifically designed to act on gut nerves without significantly crossing the blood-brain barrier, which is why it improves stomach motility without commonly causing the sedation seen with older anti-nausea medicines.
