Rabzia-LSR Capsule
Enteric Coated Rabeprazole 20 mg + Levosulpiride 75 mg (Sustained Release)
| Composition | Enteric Coated Rabeprazole 20 mg + Levosulpiride 75 mg (Sustained Release) |
|---|---|
| Packing | 10X10 Alu/Alu |
| MRP | ₹ 1760 |
| Dosage Form | Capsules |
About Rabzia-LSR Capsule
Rabzia-LSR Capsule contains Enteric Coated Rabeprazole 20 mg and Levosulpiride 75 mg (Sustained Release), combining a powerful proton pump inhibitor with a prokinetic and antiemetic agent. Rabeprazole reduces excess acid production, while the sustained-release Levosulpiride improves gastric motility, reduces nausea, and helps manage functional digestive symptoms.
This combination is designed for patients with acid reflux who also have prominent symptoms of functional dyspepsia such as persistent nausea, bloating, early satiety, and regurgitation. The enteric coating on Rabeprazole protects it from stomach acid until it reaches the right absorption site, and the sustained-release Levosulpiride ensures all-day digestive support.
Uses of Rabzia-LSR Capsule
This medicine is commonly used for:
- Acid reflux and heartburn with persistent nausea
- Functional dyspepsia with bloating and early fullness
- Gastroesophageal reflux disease (GERD) with motility dysfunction
- Regurgitation and belching associated with delayed gastric emptying
- Chronic indigestion where standard acid therapy alone is insufficient
Indications
Enteric Coated Rabeprazole 20 mg + Levosulpiride 75 mg SR is indicated for the management of gastroesophageal reflux disease with coexisting gastroparesis or impaired gastric motility, functional dyspepsia with hypersecretion and prominent nausea, and symptomatic regurgitation unresponsive to PPI monotherapy. Levosulpiride, the levo-isomer of sulpiride, provides superior prokinetic efficacy and antiemetic action by selective dopamine D2 receptor antagonism at peripheral and central levels.
How Rabzia-LSR Capsule Works
Rabzia-LSR works in two complementary ways. The enteric-coated Rabeprazole reaches the stomach's acid-producing cells and turns them off, reducing acid and giving the digestive lining a chance to recover. Levosulpiride, released slowly throughout the day, helps the stomach and intestines move food along normally, reduces nausea, and eases that uncomfortable heavy or bloated feeling after meals.
Mechanism of Action
Rabeprazole (enteric coated) is a proton pump inhibitor that selectively and irreversibly inhibits the gastric H+/K+ ATPase, reducing basal and stimulated acid secretion with rapid onset. Levosulpiride is the levorotatory enantiomer of sulpiride and a selective dopamine D2 receptor antagonist; it enhances cholinergic transmission in the myenteric plexus, increasing gastric and intestinal peristalsis, elevating lower esophageal sphincter tone, and exerting central antiemetic activity via the chemoreceptor trigger zone. The sustained-release formulation maintains steady-state plasma levels over 24 hours.
Key Benefits
- Enteric-coated Rabeprazole delivers targeted, reliable acid suppression
- Sustained-release Levosulpiride provides consistent all-day motility improvement
- Effective against both acid and non-acid functional digestive symptoms
- Reduces nausea and regurgitation beyond what acid suppression alone can achieve
Did You Know?
Levosulpiride is the active isomer of sulpiride and has been shown to have better prokinetic efficacy and a more favorable side-effect profile than the racemic mixture — a good example of how refining a molecule's structure can improve a medicine.
When & How to Take
Rabzia-LSR is generally taken before meals as directed by your doctor. The enteric-coated and sustained-release components require the capsule to be swallowed whole. Always follow your doctor's prescribed schedule and do not modify the dose on your own.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include mild headache, dry mouth, or diarrhea. Levosulpiride may occasionally cause mild drowsiness or, with prolonged high-dose use, hormonal effects such as increased prolactin — your doctor will monitor for these. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Swallow the capsule whole — do not crush or chew, as this disrupts the enteric coating and sustained release
- Inform your doctor if you have a history of any hormonal disorders or movement disorders before starting this medicine
- Tell your doctor about all other medications you take, as Levosulpiride can interact with other CNS-active drugs
- Not recommended during pregnancy or breastfeeding without medical supervision
- Long-term use should be periodically reviewed by your doctor
Myths vs Facts
If acid medicine alone isn't working for my indigestion, I just need a higher dose.
Many digestive symptoms — like bloating and nausea — are caused by poor gastric motility, not just excess acid. A prokinetic like Levosulpiride addresses a different root cause, which is why combinations like Rabzia-LSR are more effective for these symptoms than simply increasing the acid-suppressing dose.
Enteric coating is just a marketing feature.
Enteric coating is a carefully engineered design that prevents the medicine from dissolving in the acidic stomach environment and ensures it is released at the correct site in the intestines — protecting both the drug and the stomach lining.
