Zaricort-40 Injection
Triamcinolone (40mg/ml)
| Composition | Triamcinolone (40mg/ml) |
|---|---|
| Packing | 1ml |
| MRP | ₹ 160 |
| Dosage Form | Injections |
About Zaricort-40 Injection
Zaricort-40 Injection contains Triamcinolone 40 mg/ml, a synthetic corticosteroid with powerful anti-inflammatory and immunosuppressive properties. It is available as a depot (long-acting) formulation, delivering sustained therapeutic effects over several weeks from a single injection.
Biozia Lifesciences' Zaricort-40 is used by doctors in conditions ranging from joint inflammation to allergic reactions, offering a targeted, long-lasting approach to controlling inflammation when oral steroids or other therapies are insufficient.
Uses of Zaricort-40 Injection
This medicine is commonly used for:
- Relieving severe joint pain and inflammation in arthritis
- Managing severe allergic reactions and skin conditions
- Treating inflammation in tendons, bursae, and soft tissues
- Controlling flare-ups of inflammatory diseases like asthma or lupus
- Providing long-lasting pain relief in inflammatory joint conditions
Indications
Indicated for the management of inflammatory and allergic conditions including rheumatoid arthritis, osteoarthritis, bursitis, tenosynovitis, epicondylitis, acute gouty arthritis, and ankylosing spondylitis (intra-articular or periarticular use). Also indicated for severe allergic states, dermatological conditions (psoriasis, lichen planus, alopecia areata), bronchial asthma (systemic), collagen diseases, and ocular inflammatory conditions, as well as systemic therapy in certain autoimmune disorders.
How Zaricort-40 Injection Works
Zaricort-40 contains a corticosteroid that mimics the action of natural stress hormones your body produces. It works by broadly dampening the immune system's inflammatory response — reducing redness, swelling, pain, and warmth at sites of inflammation. As a depot injection, it releases the medication slowly over time, providing weeks of anti-inflammatory relief from a single dose.
Mechanism of Action
Triamcinolone acetonide is a potent fluorinated glucocorticoid that binds to intracellular glucocorticoid receptors, forming a receptor-ligand complex that translocates to the nucleus and modulates gene transcription. It upregulates anti-inflammatory proteins (lipocortin-1/annexin A1), suppresses NF-κB activation, and downregulates pro-inflammatory cytokines (IL-1, IL-6, TNF-α). It inhibits phospholipase A2 via lipocortin, reducing arachidonic acid release and subsequent prostaglandin/leukotriene synthesis. The microcrystalline depot formulation allows gradual local absorption over 3–4 weeks, maintaining therapeutic tissue concentrations.
Key Benefits
- Long-lasting anti-inflammatory effect from a single depot injection
- Targeted intra-articular delivery reduces systemic steroid exposure
- Effective across a wide range of inflammatory and allergic conditions
- Rapid and sustained reduction of swelling, pain, and stiffness
Did You Know?
Triamcinolone's depot formulation is so long-lasting that a single intra-articular injection can provide anti-inflammatory relief for up to 3 to 4 weeks — making it one of the longest-acting corticosteroid injections used in clinical practice.
When & How to Take
Zaricort-40 Injection is given by a doctor or trained healthcare professional, typically as an injection into a joint, muscle, or soft tissue, depending on the condition being treated. The frequency of repeat injections and total number of doses are decided by your doctor — do not seek re-injection without medical evaluation.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include temporary increase in blood glucose (especially in diabetic patients), pain or swelling at the injection site shortly after administration, and transient facial flushing. Long-term or repeated use may affect bone density and immunity. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Not recommended for use in patients with active infections, including fungal, viral, or bacterial infections, without concurrent antimicrobial therapy
- Use with caution in patients with diabetes, as corticosteroids can raise blood sugar levels
- Avoid live vaccines during and shortly after treatment
- Patients on long-term corticosteroid therapy should not stop suddenly without medical advice
- Inform your doctor if you have osteoporosis, high blood pressure, or a history of peptic ulcer disease
Myths vs Facts
One cortisone injection is harmless and can be taken as often as needed.
While a single injection is generally safe, repeated frequent injections in the same joint can damage cartilage and weaken surrounding tissues over time. Frequency is carefully managed by your doctor.
Steroid injections permanently cure arthritis.
Corticosteroid injections provide effective temporary relief from pain and inflammation but do not cure the underlying disease. They are part of a broader management plan.
