Coldrox Plus Tablet
Phenylephrine Hcl 5 mg + Paracetamol 325 mg + Diphenhydramine Hcl 25 mg + Caffeine 30 mg
| Composition | Phenylephrine Hcl 5 mg + Paracetamol 325 mg + Diphenhydramine Hcl 25 mg + Caffeine 30 mg |
|---|---|
| Packing | 10X10 Blister |
| MRP | ₹ 1000 |
| Dosage Form | Tablets |
About Coldrox Plus Tablet
Coldrox Plus Tablet is a multi-action cold and flu relief tablet containing Phenylephrine HCl 5 mg, Paracetamol 325 mg, Diphenhydramine HCl 25 mg, and Caffeine 30 mg. This carefully balanced combination addresses the four most troublesome symptoms of a cold all at once: nasal congestion, headache and body aches, sneezing and runny nose, and the sluggish, drowsy feeling that can make you unproductive.
Coldrox Plus from Biozia Lifesciences offers the convenience of a single tablet to manage the full cluster of cold symptoms, making it a popular choice during seasonal changes when colds and flu are common.
Uses of Coldrox Plus Tablet
This medicine is commonly used for:
- Relieving nasal and sinus congestion due to cold or allergies
- Reducing fever, headache, and body aches during cold and flu
- Controlling sneezing, runny nose, and watery eyes
- Easing throat discomfort associated with the common cold
- Helping maintain alertness and counteracting the drowsiness caused by the antihistamine component
Indications
This combination is indicated for the symptomatic relief of upper respiratory tract symptoms associated with the common cold and influenza-like illness, including rhinorrhoea, nasal congestion, sneezing, pyrexia, headache, and generalised myalgia. Phenylephrine provides nasal decongestion via alpha-1 agonism; paracetamol provides analgesia and antipyresis; diphenhydramine provides antihistaminic and anti-secretory relief for rhinorrhoea; and caffeine serves as an adjuvant analgesic and mild CNS stimulant to counteract antihistamine-induced sedation.
How Coldrox Plus Tablet Works
Each ingredient in Coldrox Plus targets a specific cold symptom. Phenylephrine narrows the swollen blood vessels in the nose to reduce congestion and stuffiness. Paracetamol reduces fever and relieves headache and body pain. Diphenhydramine blocks the histamine signals that trigger sneezing and a runny nose. Caffeine gives you a gentle energy boost, helping to counteract the drowsiness that diphenhydramine can cause.
Mechanism of Action
Phenylephrine is a selective alpha-1 adrenergic agonist that causes vasoconstriction of the nasal mucosa, reducing oedema and congestion. Paracetamol inhibits central prostaglandin synthesis via COX enzyme modulation, producing analgesia and antipyresis. Diphenhydramine is a first-generation H1-receptor antagonist with anticholinergic properties, reducing histamine-mediated secretions (rhinorrhoea), nasal itching, and sneezing; its CNS penetration also contributes mild sedation. Caffeine (30 mg) is an adenosine receptor antagonist that provides mild CNS stimulation, potentiates the analgesic effect of paracetamol, and partially offsets diphenhydramine-induced sedation.
Key Benefits
- Multi-symptom relief in one tablet — tackles congestion, pain, fever, runny nose, and drowsiness together
- Caffeine component helps you stay alert and functional during daytime use
- Fast-acting formulation for quick symptom relief
- Convenient single-tablet option reduces the need for multiple medicines
Did You Know?
Caffeine has been shown in clinical studies to enhance the pain-relieving effect of paracetamol by up to 40%, which is why it is frequently added to cold and headache combination tablets — allowing the same pain relief with a lower paracetamol dose.
When & How to Take
Coldrox Plus should be taken as directed by your doctor or pharmacist, usually with or after food to minimise stomach upset. Due to the caffeine content, it is generally more suitable for daytime use. Avoid taking at bedtime. Always follow the recommended dosing schedule and do not combine with other paracetamol-containing products.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Possible side effects include mild drowsiness (despite the caffeine), dry mouth, mild nausea, dizziness, or difficulty sleeping if taken close to bedtime. Avoid driving or operating heavy machinery until you know how this medicine affects you. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Do not take with other medicines containing paracetamol to avoid accidental overdose
- Avoid alcohol while taking this medicine — it can increase drowsiness and liver stress
- Use with caution if you have high blood pressure, heart disease, or thyroid disorders, as phenylephrine can raise blood pressure
- Not recommended for children unless specifically advised by a doctor
- Inform your doctor if you have glaucoma, enlarged prostate, or urinary difficulties, as diphenhydramine may worsen these conditions
Myths vs Facts
Cold tablets like Coldrox Plus treat the underlying cold virus.
No over-the-counter cold tablet kills the cold virus. These medicines are symptom relievers — they help you feel more comfortable while your immune system fights off the virus naturally.
More tablets mean faster relief.
Taking more than the recommended dose does not speed up recovery and increases the risk of side effects including paracetamol overdose, excessive blood pressure from phenylephrine, and severe drowsiness. Always follow the prescribed dose.
