ZIADERM 5 PLUS CREAM
KETOCONAZOLE 20 MG + IODOCHLORHYDROXYQUINOLINE 10 MG + TOLNAFTATE 10 MG + NEOMYCIN 1 MG + CLOBETASOL PROPIONATE 0.05 MG + DEXPANTHENOL 0.5 MG
| Composition | KETOCONAZOLE 20 MG + IODOCHLORHYDROXYQUINOLINE 10 MG + TOLNAFTATE 10 MG + NEOMYCIN 1 MG + CLOBETASOL PROPIONATE 0.05 MG + DEXPANTHENOL 0.5 MG |
|---|---|
| Packing | 15 gm |
| MRP | UPCOMING |
| Dosage Form | Topical |
About ZIADERM 5 PLUS CREAM
ZIADERM 5 PLUS CREAM is a multi-action topical preparation containing Ketoconazole, Iodochlorhydroxyquinoline, Tolnaftate, Neomycin, Clobetasol Propionate, and Dexpanthenol. This comprehensive combination brings together antifungal agents, an antibacterial, a steroid for inflammation control, and a soothing skin conditioner in a single cream.
It is designed for the management of complex, mixed skin infections where fungal, bacterial, and inflammatory components coexist — particularly common in warm and humid climates. The inclusion of Dexpanthenol also helps soothe and support the skin barrier during treatment.
Uses of ZIADERM 5 PLUS CREAM
This medicine is commonly used for:
- Treating mixed skin infections involving fungi and bacteria
- Managing itching, redness, and inflammation associated with infected skin conditions
- Treating ringworm and candidal skin infections with secondary bacterial involvement
- Relieving symptoms of infected eczema or dermatitis
- Soothing and conditioning irritated or infected skin during treatment
Indications
Indicated for topical management of dermatoses with mixed aetiology, including superficial fungal infections (dermatophytes and Candida) addressed by Ketoconazole and Tolnaftate, Gram-positive and Gram-negative bacterial superinfection addressed by Neomycin and Iodochlorhydroxyquinoline, inflammation and pruritus controlled by Clobetasol Propionate, and skin barrier support provided by Dexpanthenol (provitamin B5).
How ZIADERM 5 PLUS CREAM Works
ZIADERM 5 PLUS CREAM uses multiple ingredients working together: Ketoconazole and Tolnaftate attack fungi, Neomycin and Iodochlorhydroxyquinoline target bacteria, and Clobetasol relieves the itch, redness, and swelling. Dexpanthenol — a form of vitamin B5 — helps moisturise and soothe the skin so it heals more comfortably.
Mechanism of Action
Ketoconazole inhibits ergosterol biosynthesis via CYP51 inhibition, disrupting fungal membrane integrity. Tolnaftate distorts hyphae and stunts mycelial growth through interference with squalene epoxidase. Neomycin, an aminoglycoside, binds the 30S ribosomal subunit and causes misreading of mRNA, inhibiting bacterial protein synthesis. Iodochlorhydroxyquinoline (clioquinol) chelates metal ions essential for microbial enzyme function, exerting broad antibacterial and antifungal activity. Clobetasol propionate, a potent glucocorticoid, suppresses phospholipase A2 and pro-inflammatory cytokine transcription. Dexpanthenol is converted to pantothenic acid (vitamin B5) in the skin, promoting keratinocyte proliferation and supporting epidermal barrier repair.
Key Benefits
- Five active agents in one cream providing antifungal, antibacterial, and anti-inflammatory coverage
- Dexpanthenol supports skin healing and soothes irritated skin during treatment
- Addresses the polymicrobial reality of many skin infections in tropical climates
- Reduces the inconvenience and cost of using multiple separate topical preparations
Did You Know?
Dexpanthenol (provitamin B5) has been used in dermatology for decades not as a treatment for infections, but as a skin-supportive ingredient. It converts to pantothenic acid in the skin, which is essential for fatty acid synthesis and the repair of the skin's protective barrier — making it a thoughtful addition to a cream treating inflamed, infected skin.
When & How to Take
Apply ZIADERM 5 PLUS CREAM to the affected area as directed by your dermatologist, typically once or twice daily. Do not exceed the prescribed duration, particularly given the presence of Clobetasol Propionate, a potent corticosteroid. Always clean and dry the affected area before application.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Mild application-site reactions such as burning, stinging, or itching may occur. Prolonged use of clobetasol-containing preparations can lead to skin thinning or increased susceptibility to further infection. Neomycin may rarely cause a sensitisation reaction in some individuals. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- For external use only — avoid eyes, mucous membranes, and large areas of broken skin
- Do not use for longer than prescribed; clobetasol is a potent steroid requiring careful duration control
- Avoid airtight occlusive dressings unless specifically directed by your doctor
- Inform your doctor if you have any known allergy to neomycin or any component of the cream
- Not recommended for facial use over extended periods without dermatological supervision
Myths vs Facts
More ingredients in a cream always mean more risk and more side effects.
Carefully formulated multi-ingredient creams like ZIADERM 5 PLUS are designed with complementary mechanisms. When used as prescribed by a dermatologist, the combination efficiently targets complex infections that would otherwise require multiple separate treatments.
Once the itch and redness are gone, you can stop the cream.
Symptom relief, especially from the corticosteroid component, often comes before the infection is fully cleared. Stopping early may lead to a recurrence of the fungal or bacterial infection.
