Petiol Plus
Aceclofenac 100 mg + Paracetamol 325 mg + Serratiopeptidase 15mg
| Composition | Aceclofenac 100 mg + Paracetamol 325 mg + Serratiopeptidase 15mg |
|---|---|
| Packing | 10x10 Alu/Alu |
| MRP | ₹ 1500 |
| Dosage Form | Tablets |
About Petiol Plus
Petiol Plus is a combination tablet containing Aceclofenac 100 mg, Paracetamol 325 mg, and Serratiopeptidase 15 mg. This triple-action formula brings together two analgesic and anti-inflammatory agents with a proteolytic enzyme to provide comprehensive relief from pain, swelling, and inflammation.
The unique addition of Serratiopeptidase in Petiol Plus helps break down inflammatory proteins and tissue debris, reducing swelling more effectively than pain medicines alone. This makes it a commonly prescribed option for musculoskeletal pain, post-operative recovery, and conditions where both pain and oedema need to be managed.
Uses of Petiol Plus
This medicine is commonly used for:
- Joint and muscle pain including osteoarthritis and rheumatoid arthritis
- Post-operative or post-traumatic swelling and pain
- Dental pain and swelling after tooth extraction
- Back pain, neck pain, and shoulder pain
- Sports injuries and soft tissue inflammation
Indications
Aceclofenac-Paracetamol-Serratiopeptidase combination is indicated for the symptomatic management of pain and oedema associated with musculoskeletal disorders, osteoarthritis, post-operative and post-traumatic inflammation, acute dental pain, and soft tissue injuries. Aceclofenac provides potent anti-inflammatory and analgesic activity; Paracetamol contributes central analgesic and antipyretic effects; Serratiopeptidase facilitates resolution of oedema, fibrinous exudate, and inflammatory debris.
How Petiol Plus Works
Aceclofenac in Petiol Plus blocks inflammatory chemicals (prostaglandins) that cause pain and swelling at the injury site. Paracetamol acts on the brain to reduce the pain signal and lower fever if present. Serratiopeptidase is a natural enzyme that helps break down and clear away fluid and proteins that accumulate in swollen tissues, helping the swelling go down faster and supporting the healing process.
Mechanism of Action
Aceclofenac inhibits cyclooxygenase-1 and COX-2 enzymes, suppressing prostaglandin E2 synthesis at sites of inflammation and reducing vascular permeability and nociceptor sensitisation. Paracetamol modulates CNS prostaglandin synthesis and activates descending serotonergic inhibitory pathways for analgesic and antipyretic effects. Serratiopeptidase (serralysin) is a metalloprotease derived from Serratia E15 that hydrolyses bradykinin, fibrin, and other inflammatory peptides at the site of oedema, reducing tissue swelling, improving microcirculation, and accelerating resolution of post-inflammatory exudate.
Key Benefits
- Triple-action relief targeting pain, inflammation, and swelling together
- Serratiopeptidase helps reduce post-operative and post-injury swelling faster
- Broad applicability for joint, muscle, dental, and soft tissue pain
- Combines established analgesics with enzyme-assisted anti-oedema action
Did You Know?
Serratiopeptidase was originally isolated from bacteria found in the gut of silkworms, which use it to dissolve their cocoons. Scientists discovered that this same enzyme has powerful anti-inflammatory properties in the human body.
When & How to Take
Petiol Plus is generally taken after food to protect the stomach, for the duration and frequency prescribed by your doctor. Serratiopeptidase should ideally not be taken with food for optimal absorption — follow your doctor's specific guidance. Do not use for longer than recommended without medical advice.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include nausea, stomach pain, heartburn, or loose motions. Dizziness or headache may occasionally occur. Long-term use of NSAIDs can affect the stomach lining. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Inform your doctor of any stomach ulcer, liver, or kidney condition before use
- Avoid alcohol during the course of treatment
- Not recommended for use in children without specific medical advice
- Do not combine with other NSAIDs or blood-thinning medicines without a doctor's approval
- Use with caution in the elderly and those with cardiovascular disease
Myths vs Facts
Enzyme tablets like Serratiopeptidase are not real medicines.
Serratiopeptidase is a clinically studied proteolytic enzyme that helps reduce post-surgical swelling and tissue inflammation. It is a recognised therapeutic agent used alongside analgesics worldwide.
Taking pain tablets will make the injury heal faster.
Pain tablets manage the symptoms of pain and swelling but do not directly speed up tissue healing. Rest, proper treatment, and follow-up with your doctor are essential for recovery.
