Dicrex-MR Tablet
Diclofenac Potassium 50 mg + Chlorzoxazone 250 mg + Paracetamol 325 mg
| Composition | Diclofenac Potassium 50 mg + Chlorzoxazone 250 mg + Paracetamol 325 mg |
|---|---|
| Packing | 10x10 Blister |
| MRP | ₹ 920 |
| Dosage Form | Tablets |
About Dicrex-MR Tablet
Dicrex-MR Tablet combines Diclofenac Potassium 50 mg, Chlorzoxazone 250 mg, and Paracetamol 325 mg — a triple-action formulation targeting the three key components of musculoskeletal pain: inflammation, muscle spasm, and pain perception. By addressing all three simultaneously, Dicrex-MR offers more complete relief for conditions like backache, neck pain, and muscle injuries.
Manufactured by Biozia Lifesciences, Dicrex-MR is designed for adults with pain involving both inflammation and muscle tightness or spasm — conditions where an anti-inflammatory alone may be insufficient. Chlorzoxazone relaxes painful muscle spasms at the spinal cord level, complementing the analgesic and anti-inflammatory effects of diclofenac and paracetamol.
Uses of Dicrex-MR Tablet
This medicine is commonly used for:
- Relieving acute backache, neck pain, and lower back pain with muscle spasm
- Managing musculoskeletal pain from sprains, strains, and sports injuries
- Treating painful muscle spasms associated with postural problems
- Providing relief from spondylitis-related pain with muscle tightness
- Managing post-traumatic musculoskeletal pain as directed by a doctor
Indications
Diclofenac Potassium 50 mg + Chlorzoxazone 250 mg + Paracetamol 325 mg is indicated for the short-term symptomatic management of acute musculoskeletal pain syndromes with concurrent muscle spasm, including acute low back pain, torticollis, lumbago, cervical spondylosis with painful muscle guarding, post-traumatic musculoskeletal injuries, and fibromyalgia-related myalgia.
How Dicrex-MR Tablet Works
Dicrex-MR targets the full picture of muscle and joint pain from three angles. Diclofenac reduces the inflammation and swelling that cause pain at the injury site. Paracetamol acts in the brain to reduce overall pain perception and any accompanying fever. Chlorzoxazone works at the spinal cord level to relax tight, knotted muscles — breaking the pain-spasm cycle that often makes musculoskeletal injuries so debilitating. Together, they provide more complete and lasting relief.
Mechanism of Action
Diclofenac potassium inhibits COX-1/COX-2 enzymes peripherally, reducing prostaglandin synthesis and neuronal sensitisation at the inflammatory site. Paracetamol provides central analgesia and antipyresis via CNS prostaglandin inhibition and endocannabinoid system modulation. Chlorzoxazone is a centrally acting skeletal muscle relaxant that depresses spinal cord and subcortical polysynaptic reflexes involved in muscle spasm, reducing abnormal muscle tone without blocking neuromuscular transmission. Its precise mechanism involves potentiation of GABA-A receptor activity and modulation of descending inhibitory pathways, resulting in reduced muscle spindle sensitivity and muscle guarding.
Key Benefits
- Triple-action relief targeting inflammation, muscle spasm, and pain — more comprehensive than dual-component alternatives
- Chlorzoxazone breaks the painful spasm-pain cycle, often providing greater functional relief for musculoskeletal injuries
- Suitable for both acute injuries and chronic musculoskeletal conditions with muscle tightness
- Fast-acting due to the potassium salt formulation of diclofenac
Did You Know?
Chlorzoxazone may turn your urine an orange or reddish-brown colour due to its metabolite formation — this is completely harmless and simply a sign that the medicine is being metabolised normally. There is no need to stop the medicine because of this colour change.
When & How to Take
Take Dicrex-MR as directed by your doctor, with or after food. Due to the muscle relaxant (chlorzoxazone) content, drowsiness is possible — avoid driving or operating machinery until you know how you respond. Follow your doctor's prescribed duration and dose carefully.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects include mild drowsiness, dizziness, nausea, and stomach discomfort. Chlorzoxazone may cause urine to turn orange or reddish — this is harmless and not a cause for concern. Diclofenac may cause gastric irritation, particularly if taken without food. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Always take with food to minimise stomach irritation from diclofenac
- Avoid driving, operating machinery, or tasks requiring full alertness until you know how this medicine affects you, due to the sedating effect of chlorzoxazone
- Avoid alcohol — it can intensify the sedative effects of chlorzoxazone and increase liver stress
- Inform your doctor of any history of peptic ulcer, liver disease, or kidney disease
- Do not take additional NSAIDs or paracetamol-containing products alongside this medicine
Myths vs Facts
Muscle relaxants make your muscles physically weaker.
Chlorzoxazone and similar central muscle relaxants do not weaken muscles structurally. They work by reducing abnormal nerve signals from the spinal cord that are causing muscles to remain in a painful, contracted state — allowing the muscles to relax to their normal tone.
You only need the pain reliever — the muscle relaxant adds no real benefit.
In musculoskeletal pain with spasm, the spasm itself is a major source of pain. Clinical evidence shows that adding a muscle relaxant to an analgesic provides significantly better functional improvement and pain relief than pain medicines alone in conditions like acute back pain.
