Ziacal-K27 Tablet
Vitamin K27 100 mcg + Calcium Carbonate 1250 mg (eq. to elemental Calcium 500 mg) + Calcitriol 0.25 mcg + Folic Acid 5 mg + Zinc 7.5 mg + Magnesium Hydroxide 50 mg + Sodium Borate 100 mcg
| Composition | Vitamin K27 100 mcg + Calcium Carbonate 1250 mg (eq. to elemental Calcium 500 mg) + Calcitriol 0.25 mcg + Folic Acid 5 mg + Zinc 7.5 mg + Magnesium Hydroxide 50 mg + Sodium Borate 100 mcg |
|---|---|
| Packing | 10x10 Alu/Alu |
| MRP | ₹ 1900 |
| Dosage Form | Tablets |
About Ziacal-K27 Tablet
Ziacal-K27 Tablet is an advanced bone and cardiovascular mineral supplement combining Vitamin K2-7 (MK-7) 100 mcg, Calcium Carbonate 1250 mg (eq. to 500 mg elemental calcium), Calcitriol 0.25 mcg, Folic Acid 5 mg, Zinc 7.5 mg, Magnesium Hydroxide 50 mg, and Sodium Borate 100 mcg. This comprehensive formulation is designed to support bone mineralisation, direct calcium to bones rather than arteries, and provide broad micronutrient support.
The star ingredient Vitamin K2-7 activates bone-binding proteins and helps keep calcium where it belongs — in bones rather than blood vessels. Calcitriol, the active form of Vitamin D, ensures efficient calcium absorption, while Folic Acid, Zinc, and Boron round out the formula with support for cell health, enzyme function, and bone metabolism.
Uses of Ziacal-K27 Tablet
This medicine is commonly used for:
- Supporting bone density and strength in adults
- Helping direct dietary calcium into bones and away from arteries
- Nutritional support during menopause and age-related bone loss
- Supporting overall mineral nutrition including folate and zinc adequacy
- Complementing osteoporosis management as a nutritional adjunct
Indications
Ziacal-K27 is indicated as a nutritional supplement for bone health support, particularly where vitamin K2 and calcitriol supplementation may benefit bone mineralisation and calcium regulation. It is suitable as an adjunct in osteopenia, osteoporosis prevention, and in postmenopausal women. Folic acid content also supports homocysteine regulation, a cardiovascular risk factor.
How Ziacal-K27 Tablet Works
Vitamin K2-7 activates proteins such as osteocalcin that bind calcium into bones, while also activating Matrix Gla Protein that prevents calcium from depositing in arteries. Calcitriol directly promotes calcium absorption from the gut. Calcium Carbonate provides a concentrated source of elemental calcium (40% by weight), and the combination with Magnesium, Zinc, Boron, and Folic Acid supports overall bone and cellular health.
Mechanism of Action
Vitamin K2 (menaquinone-7) acts as a cofactor for gamma-carboxylase, enabling carboxylation of osteocalcin (bone Gla protein) and Matrix Gla Protein (MGP). Carboxylated osteocalcin binds calcium to hydroxyapatite in bone matrix; carboxylated MGP inhibits vascular calcification. Calcitriol (1,25-dihydroxyvitamin D3) binds vitamin D receptors in intestinal epithelium, upregulating TRPV6 channels and calbindin-D9k for transcellular calcium transport. Calcium Carbonate dissolves in gastric acid to release ionised calcium for active and passive intestinal uptake, which is why it is best taken with meals. Folic acid reduces homocysteine levels by serving as a methyl donor in the folate cycle. Zinc and Magnesium support osteoblast activity and alkaline phosphatase function. Boron modulates magnesium and phosphorus metabolism and may influence sex hormone action on bone.
Key Benefits
- Vitamin K2-7 (MK-7 form) offers prolonged activity, with a half-life far longer than K2-4, supporting consistent bone protein activation
- Directs calcium into bones and may help prevent arterial calcium deposition
- Calcitriol ensures effective calcium absorption without requiring hepatic or renal conversion
- A single tablet provides a broad spectrum of bone-supporting micronutrients
Did You Know?
Vitamin K2 in the MK-7 form, derived from the fermented soy food natto, has a half-life of over 70 hours — far longer than the MK-4 form — meaning a once-daily dose can maintain active vitamin K levels throughout the day and night.
When & How to Take
Ziacal-K27 is typically taken once daily with a meal, as directed by your doctor. Calcium carbonate needs stomach acid to be absorbed well, and the fat-soluble vitamins (K2 and calcitriol) are also absorbed better with food. Keep a gap of two to four hours from iron supplements, thyroid medicine and antibiotics such as tetracyclines or fluoroquinolones. Always follow your doctor's prescribed schedule.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Ziacal-K27 is generally well tolerated at recommended supplemental levels. Mild gastrointestinal effects such as bloating, constipation, or nausea may occasionally occur. Calcitriol at prescription doses requires monitoring for hypercalcaemia; follow your doctor's instructions carefully. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Do not take more than the prescribed dose; excess calcitriol can raise blood calcium levels
- Patients on anticoagulants (blood thinners like warfarin) should consult their doctor before taking Vitamin K supplements
- Inform your doctor if you have kidney disease, as calcitriol metabolism may be altered
- Keep your doctor informed of all other supplements and medicines you are taking
- Consult your doctor before use during pregnancy or if you have hypercalcaemia
Myths vs Facts
Vitamin K is only needed for blood clotting.
While Vitamin K1 plays the main role in clotting, Vitamin K2 (as in Ziacal-K27) primarily activates bone and vascular proteins, directing calcium into bones and helping keep arteries flexible.
If you take calcium, your bones will automatically get stronger.
Calcium alone is not enough. Without cofactors like Vitamin K2, Calcitriol, and Magnesium, calcium may not be efficiently incorporated into bone. Ziacal-K27 provides the full team needed to support bone mineralisation.
