Cofles DMR (S/F) Syrup
Dextromethorphan 15 mg.+Phenylephrine 5 mg.+ Cholrpheniramine 2 mg
| Composition | Dextromethorphan 15 mg.+Phenylephrine 5 mg.+ Cholrpheniramine 2 mg |
|---|---|
| Packing | 100 ml |
| MRP | ₹ 100 |
| Dosage Form | Syrups & Suspensions |
About Cofles DMR (S/F) Syrup
Cofles DMR (S/F) Syrup is a sugar-free combination cold and cough syrup containing Dextromethorphan 15 mg, Phenylephrine 5 mg, and Chlorpheniramine 2 mg per dose. This triple-action formulation addresses the three most troublesome symptoms of a cold simultaneously — dry, irritating cough, nasal congestion, and allergic reactions like sneezing and runny nose.
Widely prescribed by doctors for adults and older children suffering from cold and upper respiratory tract infections, Cofles DMR (S/F) Syrup delivers fast relief in one sugar-free dose, making it suitable for diabetic patients as well.
Uses of Cofles DMR (S/F) Syrup
This medicine is commonly used for:
- Suppressing dry, non-productive cough
- Relieving nasal congestion and stuffy nose
- Reducing sneezing and runny nose from colds or allergies
- Managing symptoms of upper respiratory tract infections
- Cold and flu symptom relief in adults and older children
Indications
Cofles DMR (S/F) Syrup is indicated for the symptomatic relief of dry cough, nasal congestion, and rhinorrhoea associated with the common cold, influenza, allergic rhinitis, and upper respiratory tract infections. Dextromethorphan provides central antitussive activity; Phenylephrine provides nasal and upper airway decongestant activity via alpha-1 adrenergic vasoconstriction; Chlorpheniramine provides first-generation H1-receptor antihistaminic activity to suppress allergic symptoms.
How Cofles DMR (S/F) Syrup Works
Cofles DMR (S/F) Syrup works through three complementary mechanisms: Dextromethorphan calms the cough centre in the brain so the urge to cough is reduced, Phenylephrine constricts the swollen blood vessels lining the nose and sinuses to reduce congestion, and Chlorpheniramine blocks the histamine signals that cause sneezing, itching, and watery eyes during a cold or allergy.
Mechanism of Action
Dextromethorphan acts centrally as a non-opioid antitussive by acting on sigma-1 and NMDA receptors in the medullary cough centre, raising the threshold for the cough reflex without causing respiratory depression or dependence at therapeutic doses. Phenylephrine is a selective alpha-1 adrenergic agonist that causes vasoconstriction of the mucosal blood vessels in the nasal passages and sinuses, reducing engorgement and secretion. Chlorpheniramine is a first-generation H1 receptor antagonist that competitively blocks histamine at H1 receptors on nasal mucosa, conjunctiva, and bronchial smooth muscle, thereby reducing rhinorrhoea, sneezing, lacrimation, and urticaria associated with allergic and infective upper respiratory conditions.
Key Benefits
- Three-in-one relief from cough, congestion, and runny nose in a single syrup
- Sugar-free formulation suitable for diabetic patients
- Dextromethorphan suppresses cough without causing addiction or drowsiness at therapeutic doses
- Effective for both cold- and allergy-related upper respiratory symptoms
Did You Know?
Dextromethorphan is chemically related to opioids but does not act on opioid receptors at therapeutic doses — it works through a completely different pathway and does not cause addiction or respiratory depression when used as directed, making it one of the safest antitussive medicines available.
When & How to Take
Cofles DMR (S/F) Syrup should be taken as prescribed by your doctor, usually after meals. Because Chlorpheniramine can cause drowsiness, be careful when driving or operating machinery. Follow your doctor's instructions on dose and duration.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Drowsiness is the most common side effect due to Chlorpheniramine. Mild dryness of the mouth, nose, or throat, or mild dizziness may also occur. Phenylephrine may slightly increase blood pressure in some patients. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Avoid driving or operating machinery as this syrup may cause drowsiness
- Inform your doctor if you have high blood pressure, heart disease, or prostate problems
- Do not take with other cough-cold syrups containing the same ingredients
- Avoid alcohol while taking this syrup — it worsens the sedative effect
- Consult your doctor before giving to children or elderly patients
Myths vs Facts
Taking more cough syrup will suppress the cough faster.
Exceeding the prescribed dose of Dextromethorphan does not improve cough suppression and can cause dizziness, nausea, or in high overdoses, serious neurological effects. Always take the prescribed dose.
This syrup treats the cold virus itself.
Cofles DMR relieves symptoms — cough, congestion, and sneezing — but does not kill the cold virus. The virus runs its course naturally; the syrup makes you more comfortable while it does.
