Oflozia-MS Suspension
Ofloxacin 50 mg + Metronidazole 120 mg + Simethicone 10 mg
| Composition | Ofloxacin 50 mg + Metronidazole 120 mg + Simethicone 10 mg |
|---|---|
| Packing | 60ML |
| MRP | ₹ 78 |
| Dosage Form | Syrups & Suspensions |
About Oflozia-MS Suspension
Oflozia-MS Suspension combines Ofloxacin 50 mg, Metronidazole 120 mg, and Simethicone 10 mg into a single suspension designed to tackle mixed gastrointestinal infections while providing relief from associated gas and bloating.
This triple-combination formulation by Biozia is particularly useful when both bacterial and protozoal organisms are suspected in gastrointestinal infections, reducing the need for multiple separate medicines and improving patient compliance.
Uses of Oflozia-MS Suspension
This medicine is commonly used for:
- Mixed bacterial and protozoal gastrointestinal infections
- Infectious diarrhoea with associated bloating and gas
- Amoebic dysentery and giardiasis along with bacterial co-infection
- Traveller's diarrhoea with abdominal discomfort
- Gut infections presenting with loose stools and flatulence
Indications
Ofloxacin + Metronidazole + Simethicone combination is indicated in mixed gastrointestinal infections caused by susceptible bacteria and anaerobes/protozoa, including amoebiasis, giardiasis, and bacterial gastroenteritis, particularly when bloating and flatulence are concurrent symptoms. Metronidazole targets anaerobic bacteria and protozoa while Ofloxacin covers aerobic gram-positive and gram-negative pathogens; Simethicone provides adjunctive relief of gaseous distension.
How Oflozia-MS Suspension Works
Ofloxacin kills susceptible bacteria by blocking their ability to replicate their DNA. Metronidazole disrupts the DNA of anaerobic bacteria and protozoa such as amoeba and giardia, helping to clear protozoal infections. Simethicone reduces the surface tension of gas bubbles in the gut, helping trapped gas pass more comfortably and relieving bloating.
Mechanism of Action
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and repair. Metronidazole, a nitroimidazole, is reduced intracellularly by anaerobic organisms to form reactive intermediates that cause DNA strand breakage and inhibit nucleic acid synthesis, leading to cell death in susceptible anaerobes and protozoa (Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis). Simethicone is a non-absorbable defoaming agent that decreases surface tension of mucus-entrapped gas bubbles in the GI tract, facilitating their coalescence and expulsion.
Key Benefits
- Triple-action formula addresses bacterial, protozoal, and gas-related GI symptoms together
- Reduces the need for multiple separate medicines for mixed gut infections
- Suspension form is easy to administer, especially for children
- Simethicone component provides quick symptomatic relief from bloating and flatulence
Did You Know?
Metronidazole was originally discovered in the 1950s and was one of the first effective oral treatments for amoebic dysentery, a disease that historically caused severe illness in many parts of the world.
When & How to Take
Oflozia-MS Suspension should be taken as prescribed by your doctor, typically with or without food. Shake the bottle well before each dose. Complete the full prescribed course even if symptoms improve earlier.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include nausea, a metallic taste in the mouth, vomiting, stomach upset, or headache. Dizziness or a mild skin rash may occasionally occur. These are generally mild and temporary. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Avoid alcohol throughout the course and for 48 hours after completing Metronidazole, as it can cause severe nausea and flushing
- Inform your doctor of any history of neurological disorders before taking this medicine
- Complete the full prescribed course to prevent recurrence and antibiotic resistance
- Not for self-medication — use only under medical supervision
- Inform your doctor about other medications you are taking to avoid potential interactions
Myths vs Facts
Taking three medicines together in a combination means higher risk of side effects.
Fixed-dose combinations are carefully formulated to use lower individual doses that together achieve therapeutic effect. They are designed for safety and are approved by regulatory authorities for combined use.
If diarrhoea stops quickly, the infection is fully cured and medicine can be stopped.
Stopping treatment early when symptoms resolve may leave the infection incompletely treated, allowing it to return or cause complications. Always complete the full course prescribed.
