Oflozia-OZR Suspension
Ofloxacin 50 mg + Ornidazole 125 mg + Racecadotril 15 mg
| Composition | Ofloxacin 50 mg + Ornidazole 125 mg + Racecadotril 15 mg |
|---|---|
| Packing | 30ML |
| MRP | ₹ 78 |
| Dosage Form | Syrups & Suspensions |
About Oflozia-OZR Suspension
Oflozia-OZR Suspension is a triple-combination formulation containing Ofloxacin 50 mg, Ornidazole 125 mg, and Racecadotril 15 mg, designed to provide comprehensive relief from infectious diarrhoea involving both bacterial and protozoal causes while reducing excessive fluid secretion in the gut.
This unique combination from Biozia addresses the infection at its root with two antimicrobials while Racecadotril works specifically to reduce the watery diarrhoea, offering faster symptomatic and microbiological recovery from acute gastroenteritis.
Uses of Oflozia-OZR Suspension
This medicine is commonly used for:
- Acute infectious diarrhoea with bacterial and protozoal causes
- Traveller's diarrhoea and gastroenteritis
- Amoebic dysentery and giardiasis with co-existing bacterial infection
- Watery diarrhoea with abdominal cramps in children (under medical supervision)
- Diarrhoea associated with mixed gut infections
Indications
Ofloxacin + Ornidazole + Racecadotril combination is indicated in acute secretory diarrhoea of mixed aetiology, including bacterial gastroenteritis, amoebiasis, and giardiasis. Ofloxacin covers susceptible gram-positive and gram-negative bacteria; Ornidazole targets anaerobic bacteria, Entamoeba histolytica, and Giardia lamblia; Racecadotril (acetorphan) acts as an enkephalinase inhibitor to reduce intestinal hypersecretion without affecting gut motility, making it particularly suitable for paediatric infectious diarrhoea.
How Oflozia-OZR Suspension Works
Ofloxacin targets and kills bacteria causing the gut infection by interfering with their DNA copying process. Ornidazole works similarly against anaerobic bacteria and protozoa like amoeba. Racecadotril reduces the excessive fluid that the gut secretes during infection — helping stools become less watery — without slowing down normal bowel movement, so the infection can still clear naturally.
Mechanism of Action
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV causing lethal DNA strand breaks. Ornidazole, a nitroimidazole, is selectively reduced in anaerobic organisms to cytotoxic intermediates that damage DNA and inhibit nucleic acid synthesis. Racecadotril (prodrug of thiorphan) inhibits enkephalinase (neutral endopeptidase, neprilysin) at the intestinal brush border, preventing degradation of endogenous enkephalins, which tonically inhibit adenylyl cyclase in enterocytes, thereby reducing hypersecretion of water and electrolytes into the intestinal lumen without altering intestinal motility.
Key Benefits
- Dual antimicrobial action targets both bacteria and protozoa simultaneously
- Racecadotril reduces watery stools without causing constipation or rebound effects
- Suspension form allows precise paediatric dosing
- Comprehensive approach shortens duration of diarrhoea and associated discomfort
Did You Know?
Racecadotril, one of the key ingredients in this combination, works differently from most anti-diarrhoeal drugs — it does not slow the bowel but instead reduces the gut's tendency to secrete excess fluid. This means the gut can still naturally clear the infection while diarrhoea is reduced.
When & How to Take
Oflozia-OZR Suspension should be taken as directed by your doctor. Shake the bottle well before each use. It is typically taken before meals. Follow the complete course as prescribed, even if diarrhoea resolves sooner.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include mild nausea, metallic taste, headache, or occasional dizziness. Racecadotril is generally very well tolerated. These effects are usually mild and temporary. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Avoid alcohol during treatment and for at least 48 hours after completing the course due to Ornidazole
- Ensure adequate oral rehydration (ORS) alongside this medicine to prevent dehydration
- Do not use as a substitute for oral rehydration therapy — it is complementary
- Inform your doctor about any history of liver disease or neurological conditions
- Use only as prescribed; do not self-medicate or continue beyond the prescribed duration
Myths vs Facts
Anti-diarrhoeal medicines should be avoided because they trap the infection inside.
Racecadotril works by reducing fluid secretion, not by stopping bowel movements. It does not trap pathogens, so it is considered safe to use alongside antimicrobials for infectious diarrhoea.
Once diarrhoea stops, the infection is fully cleared.
Symptomatic improvement does not always mean microbiological clearance. Completing the full prescribed antibiotic course is essential to fully eliminate the infection and prevent recurrence.
