Ziafax-180 Tablet
Fexofenadine 180 mg
| Composition | Fexofenadine 180 mg |
|---|---|
| Packing | 10x10 Alu/Alu |
| MRP | ₹ 1250 |
| Dosage Form | Tablets |
About Ziafax-180 Tablet
Ziafax-180 Tablet contains Fexofenadine 180 mg, one of the most widely trusted non-sedating antihistamines for allergy relief. Fexofenadine is the active metabolite of Terfenadine and is celebrated for its highly effective allergy symptom control with virtually no drowsiness — making it suitable for use at any time of day.
Ziafax-180 is the adult-strength tablet prescribed for seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria. Its minimal central nervous system penetration means it is one of the preferred antihistamines for patients who cannot afford any impairment in alertness.
Uses of Ziafax-180 Tablet
This medicine is commonly used for:
- Relieving sneezing, runny nose, and nasal itching due to hay fever and dust allergy
- Treating itchy, red, and watery eyes caused by seasonal allergies
- Managing chronic idiopathic urticaria (hives) and associated skin itching
- Providing all-day allergy relief without causing drowsiness
- Controlling allergy symptoms in patients who drive or work with machinery
Indications
Fexofenadine 180 mg is indicated for the symptomatic treatment of seasonal allergic rhinitis and chronic idiopathic urticaria in adults and adolescents above 12 years of age. It is preferred in situations where non-impairment of cognitive function and alertness is critical, making it suitable for professional use, vehicle operators, and patients with demanding daily activities.
How Ziafax-180 Tablet Works
Fexofenadine works by blocking H1-histamine receptors — the sites where histamine binds and causes allergy symptoms like sneezing, itching, and runny eyes. Unlike older antihistamines, it does not easily cross the blood-brain barrier, so the brain remains unaffected and there is no drowsiness. You get effective allergy relief and can stay alert throughout your day.
Mechanism of Action
Fexofenadine is a selective competitive antagonist of peripheral histamine H1-receptors. Being a substrate for the efflux transporter P-glycoprotein, it is actively pumped out of the CNS, resulting in negligible central H1-receptor occupancy. This accounts for its non-sedating profile. It does not block muscarinic, alpha-adrenergic, beta-adrenergic, dopaminergic, or serotonergic receptors at therapeutic doses, ensuring an absence of anticholinergic side effects. At 180 mg, sustained peripheral H1-receptor blockade over 24 hours is achieved.
Key Benefits
- Non-sedating formula allows full daytime use without compromising alertness
- Once-daily tablet provides sustained 24-hour allergy relief
- No anticholinergic side effects such as dry mouth or urinary retention
- Suitable for patients whose profession or lifestyle requires full cognitive function
Did You Know?
Fexofenadine in Ziafax-180 was specifically designed to be excluded from the brain. It is a substrate for P-glycoprotein, an efflux transporter in the blood-brain barrier that actively pumps fexofenadine back out of the CNS — which is why it is one of the truest non-sedating antihistamines available.
When & How to Take
Ziafax-180 is taken once daily, with water and a light meal. Avoid taking it with fruit juices (such as orange, apple, or grapefruit juice) as these can reduce absorption. Take it at the same time each day as directed by your doctor.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Fexofenadine is one of the best-tolerated antihistamines. Side effects are rare but may include headache, nausea, dizziness, or fatigue. It does not typically cause drowsiness at recommended doses. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Avoid taking Ziafax-180 with grapefruit, orange, or apple juice as they can reduce fexofenadine absorption by up to 36%
- Inform your doctor if you have kidney disease — dose adjustment may be required
- Antacids containing aluminium or magnesium may reduce absorption — take Ziafax-180 at least 2 hours apart from antacids
- Tell your doctor about all medicines you are taking, as some may interact with fexofenadine
- Consult your doctor before use in pregnancy or breastfeeding
Myths vs Facts
Non-drowsy antihistamines do not work as well as older sedating ones.
The effectiveness of an antihistamine for allergy symptoms is determined by how well it blocks H1-receptors in the body — not by whether it causes drowsiness. Fexofenadine in Ziafax-180 is a potent H1-blocker with proven clinical efficacy, equal to or better than many older antihistamines for symptom control.
You can drink orange juice with your antihistamine tablet.
Fexofenadine absorption is significantly reduced by grapefruit, orange, and apple juice due to OATP transporter inhibition in the gut. This is a well-established interaction specific to fexofenadine — always take Ziafax-180 with water, not fruit juice.
