Cofles DX (S/F-Paan) Syrup
Dextromethorphan 15 mg.+Phenylephrine 5 mg.+ Cholrpheniramine 2 mg
| Composition | Dextromethorphan 15 mg.+Phenylephrine 5 mg.+ Cholrpheniramine 2 mg |
|---|---|
| Packing | 100 ml |
| MRP | ₹ 105 |
| Dosage Form | Syrups & Suspensions |
About Cofles DX (S/F-Paan) Syrup
Cofles DX (S/F-Paan) Syrup is a sugar-free, paan-flavoured cold and cough syrup containing Dextromethorphan 15 mg, Phenylephrine 5 mg, and Chlorpheniramine 2 mg per dose. This triple combination treats the key symptoms of cold and upper respiratory infections — dry cough, blocked nose, runny nose, and sneezing — in a pleasant paan flavour that improves palatability.
The paan flavour variant of Cofles DX is particularly popular among patients who prefer a traditional Indian flavour, while still delivering the same clinically effective composition in a sugar-free formulation suitable for diabetic patients.
Uses of Cofles DX (S/F-Paan) Syrup
This medicine is commonly used for:
- Suppressing dry, irritating cough caused by colds
- Clearing nasal congestion and blocked sinuses
- Reducing sneezing, runny nose, and watery eyes
- Managing symptoms of upper respiratory infections and allergic rhinitis
- Relief from cold and flu symptoms in adults and older children
Indications
Cofles DX (S/F-Paan) Syrup is indicated for the symptomatic relief of cough, nasal congestion, and rhinorrhoea associated with the common cold, influenza, and allergic upper respiratory conditions. Dextromethorphan provides centrally acting antitussive activity; Phenylephrine provides alpha-1 adrenergic nasal decongestant activity; Chlorpheniramine provides H1 receptor antihistaminic activity for the management of allergic symptoms including rhinorrhoea and sneezing.
How Cofles DX (S/F-Paan) Syrup Works
Cofles DX (S/F-Paan) Syrup works through three complementary actions: Dextromethorphan suppresses the cough reflex in the brain to quieten a persistent dry cough, Phenylephrine shrinks the swollen blood vessels inside the nose to unblock it, and Chlorpheniramine blocks the histamine signals responsible for sneezing, itching, and a runny nose.
Mechanism of Action
Dextromethorphan acts as a centrally active antitussive via sigma-1 receptor agonism and NMDA receptor antagonism in the nucleus tractus solitarius, elevating the cough reflex threshold without significant respiratory depression or opioid-type dependence. Phenylephrine selectively agonises alpha-1 adrenergic receptors on nasal mucosal vasculature, causing vasoconstriction that reduces mucosal engorgement and nasal secretion volume. Chlorpheniramine is a reversible, competitive H1 receptor antagonist; its central and peripheral H1 blockade reduces histamine-mediated vascular permeability, glandular secretion, and smooth muscle spasm responsible for rhinorrhoea, sneezing, and ocular symptoms in allergic and infective upper respiratory states.
Key Benefits
- Effective three-in-one cold symptom relief in a single convenient syrup
- Paan flavour improves palatability and patient compliance
- Sugar-free — safe for diabetic patients
- Dextromethorphan suppresses cough without the risk of dependence at therapeutic doses
Did You Know?
The paan flavour in Cofles DX is not just about taste — better-tasting medicines have been shown in studies to significantly improve adherence to treatment, especially for syrups taken multiple times a day during illness, leading to better outcomes overall.
When & How to Take
Cofles DX (S/F-Paan) Syrup should be taken as prescribed by your doctor, usually after meals. Chlorpheniramine can cause drowsiness, so be cautious with driving or machinery use. Do not alter the prescribed dose or frequency.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Drowsiness is the most common side effect due to Chlorpheniramine. Some patients may experience dryness of the mouth, mild dizziness, or mild increase in blood pressure from Phenylephrine. These effects are usually temporary. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Avoid driving or operating heavy machinery as this syrup may cause drowsiness
- Inform your doctor if you have high blood pressure, heart disease, glaucoma, or prostate enlargement
- Do not combine with other cold medicines containing the same active ingredients
- Avoid alcohol while taking this syrup
- Keep out of reach of children
Myths vs Facts
Cold syrups with antihistamines treat the cold virus.
Antihistamines like Chlorpheniramine treat the symptoms of a cold — sneezing, runny nose — not the virus itself. The cold resolves on its own; the syrup keeps you comfortable while it does.
Sugar-free means the medicine is less effective.
The sugar-free formulation of Cofles DX only removes added sugar — it does not change the active ingredients or their effectiveness. It is equally effective and safer for diabetic patients.
