Cofles LS Syrup (S/F)
Ambroxol HCL 30 mg. + Guaphenesin 50 mg. + Levosalbutamol 1 mg
| Composition | Ambroxol HCL 30 mg. + Guaphenesin 50 mg. + Levosalbutamol 1 mg |
|---|---|
| Packing | 100 ml |
| MRP | ₹ 99 |
| Dosage Form | Syrups & Suspensions |
About Cofles LS Syrup (S/F)
Cofles LS Syrup is a sugar-free combination cough and cold syrup containing Ambroxol HCl 30 mg, Guaifenesin 50 mg, and Levosalbutamol 1 mg. This triple-action formulation targets multiple aspects of productive cough and airway obstruction — thinning mucus, helping it clear, and opening narrowed airways simultaneously.
Cofles LS Syrup is particularly suited for patients with wet, productive cough associated with conditions like asthma, bronchitis, or COPD, where mucus accumulation and bronchospasm both need to be addressed. The sugar-free formulation makes it appropriate for diabetic patients.
Uses of Cofles LS Syrup (S/F)
This medicine is commonly used for:
- Relieving productive (wet) cough with thick or sticky mucus
- Opening up narrowed airways in asthma and bronchitis
- Thinning and loosening mucus so it can be coughed out more easily
- Managing cough and breathing difficulty in chronic obstructive pulmonary disease (COPD)
- Relieving chest tightness and wheezing with cough
Indications
Cofles LS Syrup is indicated in the management of productive cough associated with acute and chronic bronchitis, bronchial asthma, COPD, and other obstructive airway diseases where mucociliary clearance is impaired and bronchospasm is present. Ambroxol provides mucokinetic and mucolytic activity; Guaifenesin acts as an expectorant; Levosalbutamol provides selective beta-2 adrenergic bronchodilation to relieve bronchospasm and facilitate mucus expulsion.
How Cofles LS Syrup (S/F) Works
Cofles LS Syrup works through three complementary actions: Ambroxol breaks down thick mucus and stimulates the tiny hair-like cilia in the airways to sweep it upward, Guaifenesin thins the mucus and helps move it out, and Levosalbutamol relaxes the muscles around the airways so they open wider and breathing becomes easier. Together, these actions give fast and thorough relief from congested, wheezy, productive coughs.
Mechanism of Action
Ambroxol HCl stimulates type II pneumocytes to increase surfactant secretion, depolymerises mucopolysaccharide strands in mucus to reduce viscosity, and enhances mucociliary beat frequency. Guaifenesin acts as an expectorant by increasing the volume of respiratory secretions through irritation of the gastric mucosa and reflex activation of secretory glands, reducing mucus adhesiveness. Levosalbutamol is the pharmacologically active R-enantiomer of salbutamol; it selectively binds beta-2 adrenergic receptors on bronchial smooth muscle, activating adenylate cyclase to raise intracellular cAMP, causing smooth muscle relaxation and bronchodilation with fewer cardiac side effects than the racemic mixture.
Key Benefits
- Triple-action formula addresses mucus, expectorant, and bronchospasm in one dose
- Sugar-free formulation safe for diabetic patients
- Levosalbutamol causes fewer palpitations than standard salbutamol
- Effective for both acute and chronic respiratory conditions with productive cough
Did You Know?
Levosalbutamol (the R-enantiomer of salbutamol) was developed specifically to provide bronchodilation with fewer side effects — such as reduced tremors and less heart rate elevation — compared to the older racemic salbutamol formulations, making it a preferred bronchodilator ingredient in combination cough syrups.
When & How to Take
Cofles LS Syrup should be taken as prescribed by your doctor. It is usually taken after meals to reduce the chance of stomach upset. Do not take more than the prescribed amount or for longer than advised.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include mild nausea, tremor, headache, or a slight increase in heart rate due to Levosalbutamol. Ambroxol may occasionally cause mild gastric discomfort. These effects are usually mild and transient. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Inform your doctor if you have heart disease, hyperthyroidism, or uncontrolled diabetes
- Use with caution in patients with hypertension — Levosalbutamol can mildly increase blood pressure
- Do not drive or operate heavy machinery if you feel dizzy after taking this syrup
- Keep out of reach of children
- Do not exceed the prescribed dose — do not combine with other bronchodilator syrups without medical advice
Myths vs Facts
Cough syrups with bronchodilators are only for asthma patients.
Bronchodilators in cough syrups like Cofles LS help anyone whose airways are narrowed due to mucus buildup or inflammation — including people with acute bronchitis, COPD, or a severe productive cough, not just diagnosed asthma patients.
Taking a higher dose of cough syrup clears congestion faster.
Exceeding the prescribed dose does not improve mucus clearance and significantly increases the risk of side effects like tremors, rapid heart rate, and nausea. Always follow your doctor's prescribed dose.
