Colinap Dry Syrup
Colistin Sulphate for Oral Suspension IP 12.5 mg per 5 ml (with sterile water for reconstitution)
| Composition | Colistin Sulphate for Oral Suspension IP 12.5 mg per 5 ml (with sterile water for reconstitution) |
|---|---|
| Packing | 30ml (with water) |
| MRP | ₹ 78 |
| Dosage Form | Dry Syrups |
About Colinap Dry Syrup
Colinap Dry Syrup contains Colistin Sulphate, a polymyxin antibiotic, as a powder for oral suspension in an orange-flavoured paediatric formulation. Each 5 ml of reconstituted suspension provides 12.5 mg of Colistin Sulphate. The pack includes sterile water for accurate reconstitution.
When taken by mouth, colistin is very poorly absorbed into the bloodstream. It therefore acts mainly inside the intestine, where it targets susceptible gram-negative bacteria responsible for certain types of bacterial diarrhoea in children.
Uses of Colinap Dry Syrup
This medicine is commonly used for:
- Treatment of bacterial diarrhoea and gastroenteritis caused by susceptible gram-negative organisms
- Infective diarrhoea in children when a bacterial cause is suspected by the doctor
- Intestinal infections caused by susceptible strains of E. coli, Shigella and Salmonella, as prescribed
Indications
Indicated for the treatment of intestinal infections and bacterial diarrhoea caused by colistin-susceptible gram-negative organisms in paediatric patients, as prescribed by a registered medical practitioner. Oral rehydration remains essential alongside antibiotic therapy.
How Colinap Dry Syrup Works
Colinap works inside the gut. Because very little of the medicine is absorbed into the blood, it stays in the intestine where it attacks the outer layer of certain harmful bacteria, killing them and helping the diarrhoea settle.
Mechanism of Action
Colistin is a cationic polypeptide antibiotic. It binds to the lipopolysaccharide and phospholipids of the outer membrane of gram-negative bacteria, displacing calcium and magnesium ions. This disrupts membrane integrity, increases permeability and leads to leakage of cell contents and bacterial death. Oral colistin is minimally absorbed, giving high intraluminal concentrations with low systemic exposure.
Key Benefits
- Acts locally in the intestine with minimal absorption into the bloodstream
- Paediatric orange-flavoured formulation for easier acceptance
- Supplied with sterile water for convenient and accurate reconstitution
- Targets common gram-negative causes of bacterial diarrhoea
Did You Know?
Colistin is considered a last-resort antibiotic for serious drug-resistant infections. To protect its effectiveness, India banned the use of colistin in food-producing animals and animal feed in 2019. Using it only when prescribed helps slow antibiotic resistance.
When & How to Take
Reconstitute the powder with the sterile water provided, following the instructions on the carton, and shake well before every dose. Give the dose and for the duration prescribed by your child's doctor, using a proper measuring device. Continue oral rehydration solution (ORS) as advised.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Oral colistin is generally well tolerated because very little is absorbed. Nausea, vomiting, abdominal discomfort or skin rash may occasionally occur. Contact your doctor if your child develops a rash, persistent vomiting, blood in stools or signs of dehydration.
Precautions & Safety
- For paediatric use only, as prescribed by a doctor
- Use only for bacterial diarrhoea - it does not work against viral diarrhoea
- Inform the doctor if the child has kidney problems or myasthenia gravis
- Complete the full course even if the child feels better
- Use the reconstituted suspension within the period stated on the label and store as directed
Myths vs Facts
Every case of diarrhoea in children needs an antibiotic.
Most childhood diarrhoea is viral and settles with ORS, zinc and continued feeding. Antibiotics like colistin are needed only when a doctor suspects a bacterial cause.
Once the diarrhoea stops, the antibiotic can be stopped.
Stopping early can allow bacteria to survive and become resistant. Complete the course your doctor has prescribed.
