Ziacox-120 Tablet
Etoricoxib 120 mg
| Composition | Etoricoxib 120 mg |
|---|---|
| Packing | 10x10 Alu/Alu |
| MRP | ₹ 1200 |
| Dosage Form | Tablets |
About Ziacox-120 Tablet
Ziacox-120 Tablet contains Etoricoxib 120 mg, the highest commonly available strength of this selective COX-2 inhibitor. Etoricoxib provides powerful anti-inflammatory and analgesic relief for acute and chronic pain conditions while having a lower risk of gastrointestinal complications compared to non-selective NSAIDs.
The 120 mg strength of Ziacox-120 is typically prescribed for short-term management of acute conditions such as gout flares, where rapid, strong anti-inflammatory activity is needed. It is used under a doctor's supervision due to its higher dose and the importance of careful patient selection.
Uses of Ziacox-120 Tablet
This medicine is commonly used for:
- Providing fast relief during acute gout attacks
- Managing severe pain and inflammation in musculoskeletal conditions
- Controlling acute postoperative pain as directed by a doctor
- Short-term treatment of intense arthritis pain flare-ups
- Relieving significant inflammatory pain when lower doses are insufficient
Indications
Etoricoxib 120 mg is indicated for the short-term treatment of acute gouty arthritis and for the management of moderate to severe acute pain conditions including postoperative dental pain and acute musculoskeletal pain, in adults. It is the highest approved Etoricoxib dose and is generally recommended for short-term use only, not for chronic daily administration.
How Ziacox-120 Tablet Works
Ziacox-120 works by selectively blocking an enzyme called COX-2, which the body uses to produce prostaglandins — the chemicals responsible for pain, swelling, and fever. By targeting COX-2 specifically, it reduces inflammation and relieves pain effectively while being gentler on the stomach compared to traditional pain killers that block both COX-1 and COX-2.
Mechanism of Action
Etoricoxib is a highly selective inhibitor of cyclo-oxygenase-2 (COX-2) with a selectivity ratio approximately 100-fold greater for COX-2 over COX-1. It inhibits prostaglandin synthesis at the site of inflammation — particularly PGE2 and PGI2 — reducing vasodilation, vascular permeability, and sensitisation of peripheral nociceptors. Because COX-1-mediated gastroprotective prostaglandins are largely spared, gastrointestinal mucosal integrity is better preserved than with non-selective NSAIDs. At 120 mg, peak plasma concentration provides prompt and potent prostaglandin suppression suitable for acute inflammatory states such as gout.
Key Benefits
- Potent and rapid anti-inflammatory relief for acute, severe conditions
- Selective COX-2 inhibition provides a more stomach-friendly alternative to conventional NSAIDs
- Convenient once-daily dosing even at the highest strength
- Particularly effective for acute gout attacks — one of the most painful inflammatory conditions
Did You Know?
Etoricoxib is one of the most selective COX-2 inhibitors available — with over 100-fold selectivity for COX-2 over COX-1. This high selectivity means it can suppress inflammation powerfully while leaving the protective prostaglandins of the stomach largely intact, reducing the risk of peptic ulcers compared to older NSAIDs.
When & How to Take
Ziacox-120 is taken once daily as prescribed by your doctor, with or without food. The 120 mg strength is typically for short-term use only. Never take it for longer than your doctor recommends, and always use the lowest effective dose.
Always follow the dosage and schedule advised by your doctor — this is general guidance only.
Possible Side Effects
Common side effects may include headache, dizziness, stomach discomfort, oedema (fluid retention), and elevated blood pressure. Like all COX-2 inhibitors, Etoricoxib carries cardiovascular and renal precautions with long-term use. Tell your doctor if any side effect is severe or persistent.
Precautions & Safety
- Not recommended for patients with established heart disease, stroke history, or uncontrolled high blood pressure
- Inform your doctor if you have kidney or liver disease
- Avoid in patients with known allergy to NSAIDs or aspirin
- The 120 mg dose is intended for short-term use only — do not extend without medical advice
- Monitor blood pressure regularly during treatment, especially with prolonged use
Myths vs Facts
COX-2 inhibitors are completely safe for the stomach.
COX-2 inhibitors like Etoricoxib in Ziacox-120 are certainly gentler on the stomach than traditional NSAIDs, but they are not entirely risk-free — especially at higher doses or with prolonged use. People with a history of ulcers should still use caution and consult their doctor.
A stronger NSAID dose is always better for pain.
The appropriate dose depends on the condition being treated. The 120 mg strength of Ziacox-120 is specifically suited to acute, severe conditions like gout — for chronic conditions, a lower dose is typically prescribed to minimise risks. More is not always better.
